The retention signal for soluble proteins of the endoplasmic reticulum
Trends in Biochemical SciencesPublished 1 December 1990
Hugh R.B. Pelham
Citations534
SJR quartileQ1
SJR score4.16
SNIP2.34
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TL;DR
The lumen of the endoplasmic reticulum contains a number of soluble proteins, many of which help the maturation of newly synthesized secretory proteins, which are thought to be recognized by a membrane-bound receptor that continually retrieves proteins from a later compartment of the secretory pathway and returns them to the ER.
Abstract
The lumen of the endoplasmic reticulum (ER) contains a number of soluble proteins, many of which help the maturation of newly synthesized secretory proteins. Retention of these resident proteins in the ER is dependent on a carboxy-terminal signal, which in animal cells is usually Lys-Asp-Glu-Leu (KDEL). This signal is thought to be recognized by a membrane-bound receptor that continually retrieves the proteins from a later compartment of the secretory pathway and returns them to the ER.
Keywords
Biochemistry, Genetics and Molecular Biology
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