CD8+ T cell contraction is controlled by early inflammation
Nature ImmunologyPublished 11 July 2004
Vladimir P. Badovinac, Brandon Porter, John T. Harty
Citations314
SJR quartileQ1
SJR score10.39
SNIP3.81
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TL;DR
Antibiotic treatment before Listeria monocytogenes infection induced numbers of protective memory CD8+ T cells similar to those in control infected mice, by a pathway without contraction, and the absence of contraction correlated with decreased early inflammation and interferon-γ production.
Abstract
Pathogen-specific CD8(+) T cells expand in number after infection and then their numbers invariably contract by 90-95%, leaving a stable memory cell pool. The chief features of this response are programmed early after infection; however, the factors regulating contraction are mostly undefined. Here we show that antibiotic treatment before Listeria monocytogenes infection induced numbers of protective memory CD8(+) T cells similar to those in control infected mice, by a pathway without contraction. The absence of contraction correlated with decreased early inflammation and interferon-gamma production and an increased fraction of CD8(+) T cells expressing the interleukin 7 receptor at the peak of the response. Thus, contraction is controlled by early inflammation but is not essential for the generation of protective memory CD8(+) T cells after infection.
Keywords
Immunology and Microbiology
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