Characterisation of an adrenal zona glomerulosa-stimulating component of posterior pituitary extracts as α-MSH
NaturePublished 1 April 1980
Gavin P. Vinson, Barbara J. Whitehouse, Anne Dell, Tony Etienne, Howard R. Morris
Citations84
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
The purification from posterior pituitary extracts of activities that stimulate rat glomerulosa cells and whole tissue in vitro is described, and one of the active compounds has been identified as α-MSH (melano-cyte stimulating hormone).
Abstract
The secretion of aldosterone from the zona glomerulosa of the mammalian adrenal cortex is stimulated by ACTH, potassium, angiotensin II and III, growth hormone, serotonin and E series prostaglandins. Some experimental and clinical studies suggest that additional stimulants of the zona glomerulosa must exist, possibly including pituitary factors other than ACTH. The possibility that posterior pituitary extracts may contain a zona glomerulosa stimulant was first suggested 20 years ago, but has since received little attention. We describe here the purification from posterior pituitary extracts of activities that stimulate rat glomerulosa cells and whole tissue in vitro. One of the active compounds has been identified as alpha-MSH (melanocyte stimulating hormone).
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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