Effects of induction of anti-embryonation immunity on liver granulomas, spleen weight and portal pressure in mice infected with Schistosoma japonicum
Acta TropicaPublished 1 March 1989
E. G. Garcia, Pilarita T. Rivera, Graham F. Mitchell, R.R. Evardome, R. Almonte, W.U. Tiu
Citations9
SJR quartileQ1
SJR score0.75
SNIP0.99
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TL;DR
The results strongly support the hypothesis that it should be possible to prevent serious hepatosplenic disease in schistosomiasis japonica by vaccination to induce anti-embryonation immunity.
Abstract
BALB/c mice sensitized with injections of viable immature Schistosoma japonicum eggs had significantly fewer and smaller granulomas in the liver, lower portal pressure and smaller spleens at D + 75 of infection compared to similarly infected unsensitized controls. The portal pressure and spleen weights of the mice sensitized with immature eggs were not different from uninfected unsensitized mice of similar ages at D + 75 of infection. The results strongly support our hypothesis that it should be possible to prevent serious hepatosplenic disease in schistosomiasis japonica by vaccination to induce anti-embryonation immunity.
Keywords
Immunology and MicrobiologyMedicineEnvironmental Science
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