Altered Neural Substrates of Cognitive Control in Childhood ADHD: Evidence From Functional Magnetic Resonance Imaging
American Journal of PsychiatryPublished 31 August 2005Open access
Chandan J. Vaidya, Silvia A. Bunge, Nicole M. Dudukovic, Christine A. Zalecki, Glen R. Elliott, John D. E. Gabrieli
Citations265
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TL;DR
Altering in the neural basis of two cognitive control operations in childhood ADHD was characterized by distinct, rather than unitary, patterns of functional abnormality, suggesting that components of cognitive control are differentially sensitive to ADHD.
Abstract
Alteration in the neural basis of two cognitive control operations in childhood ADHD was characterized by distinct, rather than unitary, patterns of functional abnormality. Greater between-group overlap in the neural network activated for interference suppression than in response inhibition suggests that components of cognitive control are differentially sensitive to ADHD. The ADHD children's inability to activate the caudate nucleus constitutes a core abnormality in ADHD. Observed functional abnormalities did not result from prolonged stimulant exposure, since most children were medication naive.
Keywords
MedicineNeuroscience
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