Vascular Risk Factors and Diabetic Neuropathy
New England Journal of MedicinePublished 27 January 2005Open access
Solomon Tesfaye, Nish Chaturvedi, Simon E.M Eaton, John D. Ward, Christos Manes, C Ionescu-Tîrgovişte
Citations1,259
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
It is indicated that, apart from glycemic control, the incidence of neuropathy is associated with potentially modifiable cardiovascular risk factors, including a raised triglyceride level, body-mass index, smoking, and hypertension.
Abstract
This prospective study indicates that, apart from glycemic control, the incidence of neuropathy is associated with potentially modifiable cardiovascular risk factors, including a raised triglyceride level, body-mass index, smoking, and hypertension.
Keywords
Medicine
Clinical ChemistryEstimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge
32,475 Citations1972William T. Friedewald, Robert I. Levy +1 more
A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented and comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99.
Clinical ChemistryQuantitative Determination of Serum Triglycerides by the Use of Enzymes
3,197 Citations1973Giovanni Bucolo, H David
A novel method for determining serum triglycerides, in which an enzymatic hydrolysis replaces the more commonly used saponification procedure, which is simple, rapid, and requires only 50 µl or less of sample.
DiabetologiaA multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population
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Journal of Lipid ResearchA comprehensive evaluation of the heparin–manganese precipitation procedure for estimating high density lipoprotein cholesterol
1,259 Citations1978G. Russell Warnick, J J Albers
The present heparin-Mn(2+) procedure was found to be reasonably specific and not often subject to large errors; however, 9% (primarily hypertriglyceridemic samples) of the 966 plasma samples treated with heparin-Mn(2+) had obvious supernatant turbidity, indicating incomplete sedimentation of apoB-associated lipoproteins.
Clinical ChemistryReagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency.
946 Citations1983J Siedel, E. Hägele +2 more
A new enzymatic cholesterol reagent (Monotest Cholesterol, High Performance, Boehringer Mannheim) gives virtually complete cholesterol ester cleavage and uses with its improved lipolytic efficiency yields results for serum total cholesterol that are identical to those measured with a candidate reference procedure involving alkaline cholesterol esters saponification.
DiabetologiaPrevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study
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DiabetologiaVascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy
692 Citations2001Norman E. Cameron, Simon E.M Eaton +2 more
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610 Citations2000Katherine V. Williams, John R. Erbey +3 more
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Annals of Internal MedicineThe Effect of Intensive Diabetes Therapy on the Development and Progression of Neuropathy
600 Citations1995The Diabetes Control and Complications Trial Research Group.
Intensive diabetes therapy prevented the development and retarded the progression of diabetic retinopathy and nephropathy at the expense of a threefold increase in the number of severe hypoglycemic events.
DiabetologiaDiabetic neuropathies
442 Citations2000Aaron I. Vinik, T. S. Park +2 more
There must be refinements in the ability to measure quantitatively the different types of defects that occur in this disorder, so that appropriate therapies can be targeted to specific fibre types.
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Traditional cardiovascular risk factors (e.g., lipids and smoking) are important determinants of distal symmetric polyneuropathy and if confirmed in prospective follow-up, open new avenues to the prevention of diabetic neuropathy.
DiabetologiaMethodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM Complications Study
373 Citations1995S J Aldington, Eva M. Kohner +4 more
A new system of 45‡ field grading standards for the assessment of diabetic retinopathy proved to be acceptably accurate, repeatable and relatively simple to apply and is particularly useful for large epidemiological studies, in which participating centres have a limited experience in retinal photography.
DiabetesInsulin Resistance is a Prominent Feature of Insulin-dependent Diabetes
367 Citations1982Ralph A. DeFronzo, Rosa Hendler +1 more
The present results indicate that impaired insulin action is a common feature of insulin-dependent diabetics, despite daily insulin requirements that would not clinically characterize them as being insulin resistant.
DiabetologiaMicrovascular and acute complications in IDDM patients: the EURODIAB IDDM Complications Study
345 Citations1994Judith Stephenson, J. H. Fuller +1 more
Microvascular and acute complications were clearly related to duration of diabetes and to glycaemic control, however, the relation of glycaemia control to raised albuminuria differed qualitatively from its relation to retinopathy.
Diabetes CareRisk factors for severity of diabetic polyneuropathy: intensive longitudinal assessment of the Rochester Diabetic Neuropathy Study cohort.
327 Citations1999P. James B. Dyck, Jenny L. Davies +4 more
It is found that diabetic microvessel disease, chronic hyperglycemia exposure, and type of diabetes are associated with severity of DPN, and it is believed these factors are implicated in its cause.
American Journal of EpidemiologySENSORY NEUROPATHY IN NON-INSULIN-DEPENDENT DIABETES MELLITUS
282 Citations1990Gary M. Franklin, LOUISE B. KAHN +3 more
A screening neurologic examination capable of detecting distal symmetric (sensory) neuropathy in a large population-based study of non-insulin-dependent diabetes mellitus in San Luis Valley, Colorado, in 1984-1986 is described and validated.
Diabetes CareRisk Factors for Coronary Heart Disease in Type 1 Diabetic Patients in Europe
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Diabetes CareSymptoms of Sensory Neuropathy in Adults with NIDDM in the U.S. Population
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Diabetes CareMarkers of Insulin Resistance Are Strong Risk Factors for Retinopathy Incidence in Type 1 Diabetes: The EURODIAB Prospective Complications Study
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Key risk factors include diabetes duration and glycemic control, with no evidence of a threshold for the latter, and independent risk factors, such as waist-to-hip ratio and triglyceride levels, both markers of insulin resistance, were strongly related to incidence.
Kidney InternationalMicroalbuminuria in type 1 diabetes: Rates, risk factors and glycemic threshold
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The incidence of microalbuminuria in patients with type 1 diabetes remains high, and there is no apparent glycemic threshold for it, and markers of insulin resistance, such as triglyceride and WHR, are strong risk factors.
DiabetesHypertension as a Risk Factor for Diabetic Neuropathy: A Prospective Study
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It is indicated that in addition to good glycemic control, avoidance of smoking and good blood pressure control may be helpful in preventing or delaying the onset of DSP in IDDM patients.
DiabetologiaImpaired blood flow and arterio-venous shunting in human diabetic neuropathy: a novel technique of nerve photography and fluorescein angiography
177 Citations1993Solomon Tesfaye, N. Harris +5 more
New techniques of sural nerve photography and fluorescein angiography which are able to provide an index of nerve blood flow have been developed and enabled us to observe that epineurial vessel anatomy is abnormal and that nerveBlood flow is impaired in subjects with chronic sensory motor neuropathy.
Diabetic MedicineVibration Perception Threshold: Influence of Age, Height, Sex, and Smoking, and Calculation of Accurate Centile Values
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Age was confirmed to be the major determinant of VPT levels at all sites and height was a significant factor for toes and ankles but not thumbs, and sex had no overall effect at toe or thumb but there were differences regarding ankle VPT.
DiabetologiaRisk factors for mortality in Type II (non-insulin-dependent) diabetes: evidence of a role for neuropathy and a protective effect of HLA-DR4
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Journal of Clinical EpidemiologyShowing neuropathy is related to increased mortality in diabetic patients — a survival analysis using an accelerated failure time model
121 Citations2000D.V. Coppini, Phil Bowtell +3 more
Diabetes CareNoninvasive Detection of Functional Alterations of the Arterial Wall in IDDM Patients With and Without Microalbuminuria
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A reduced vasodilatory capacity in diabetes mellitus is confirmed, with a more marked alteration in microalbuminuric diabetic subjects, and this reliable, noninvasive evaluation of arterial function is particularly useful for early diagnosis of vascular involvement.
Diabetes CareCigarette Smoking and Neuropathy in Diabetic Patients
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The method was linear within the expected range of results and showed good correlation with established methods for estimating glycohemoglobin, while the percentages of hemoglobin that were HbA1c in diabetics were significantly greater than in nondiabetics.
Journal of Clinical PathologySimple immunoturbidimetric method for determining urinary albumin at low concentrations using Cobas-Bio centrifugal analyser.
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Diabetes CareInfluence of Height on Quantitative Sensory, Nerve-Conduction, and Clinical Indices of Diabetic Peripheral Neuropathy
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Thrombosis and HaemostasisRelationships between Haemostatic Factors and Capillary Morphology in Human Diabetic Neuropathy
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MetabolismLow-density lipoprotein particle size and coronary artery disease in a childhood-onset type 1 diabetes population
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