Surface Proteins and Exotoxins Are Required for the Pathogenesis of<i>Staphylococcus aureus</i>Pneumonia
Infection and ImmunityPublished 14 November 2006Open access
Juliane Bubeck Wardenburg, Ravi J. Patel, Olaf Schneewind
Citations345
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TL;DR
A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described, which closely mimics the clinical and pathological features of pneumonia in human patients.
Abstract
A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.
Keywords
Immunology and MicrobiologyBiochemistry, Genetics and Molecular Biology
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