Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
NaturePublished 1 August 1988
Karen Yamamoto, G. González, William Biggs, Marc Montminy
Citations1,320
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
Findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.
Abstract
A nuclear protein, CREB, has been isolated from rat brain and shown to stimulate transcription of the cyclic AMP-responsive gene somatostatin as a dimer. Biochemical analysis suggests that dimerization and transcriptional efficacy of CREB protein in vitro are regulated by phosphorylation. These findings demonstrate that cellular signals can modulate gene expression by regulating the covalent modification of pre-existing nuclear factors.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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