FK-506 and cyclosporin A : immunosuppressive mechanism of action and beyond
Current Opinion in ImmunologyPublished 1 January 1992
John J. Siekierka, N H Sigal
Citations85
SJR quartileQ1
SJR score2.74
SNIP1.38
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TL;DR
Two new gene families are identified whose products may function as components of several diverse signal transduction pathways in both lymphocytic and other cell types in the presence of the immunosuppressive drugs.
Abstract
Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation. Research efforts aimed at elucidating the molecular mechanism of action of these drugs have, in addition to defining their immunosuppressive functions, led to the identification of two new gene families whose products may function as components of several diverse signal transduction pathways. In the presence of the immunosuppressive drugs, some members of the receptor families interact with the Ca2+/calmodulin-dependent protein phosphatase 2B, also known as calcineurin. Inhibition of phosphatase activity may effect several downstream biochemical processes. In this way, cyclosporin A and FK-506 have proved to be useful probes of signaling events in both lymphocytic and other cell types.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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