Vasoactive Intestinal Peptide Stimulation of Pineal Serotonin‐<i>N</i>‐Acetyltransferase Activity: General Characteristics
Journal of NeurochemistryPublished 1 January 1983
Arthur Yuwiler
Citations87
SJR quartileQ1
SJR score1.50
SNIP1.02
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TL;DR
Intravenous administration of VIP can increase pineal NAT activity in vivo, and the magnitude of the pineal response to VIP varies with age, is greater in pineals maintained in 48‐h organ culture than in those in acute culture, and can be detected in Pineals from newborns after 48‐H organ culture.
Abstract
Vasoactive intestinal polypeptide (VIP) stimulates basal serotonin-N-acetyltransferase (NAT) activity in pineals in organ culture and enhances the effects of catecholamines in inducing the enzyme. VIP appears to act postsynaptically; its action is independent of the beta receptor and is dependent upon protein synthesis. Its effects may be mediated by a receptor. The magnitude of the pineal response to VIP varies with age, is greater in pineals maintained in 48-h organ culture than in those in acute culture, and can be detected in pineals from newborns after 48-h organ culture. Intravenous administration of VIP can increase pineal NAT activity in vivo.
Keywords
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