Associations of maternal obesity with blood pressure and the risks of gestational hypertensive disorders. The Generation R Study
Journal of HypertensionPublished 24 March 2011
Romy Gaillard, Eric A.P. Steegers, Albert Hofman, Vincent W. V. Jaddoe
Citations146
SJR quartileQ1
SJR score1.10
SNIP1.63
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Maternal obesity and morbid obesity are strongly associated with blood pressure in each trimester, and increased risks of gestational hypertensive disorders.
Abstract
Maternal obesity and morbid obesity are strongly associated with blood pressure in each trimester, and increased risks of gestational hypertensive disorders.
Keywords
Medicine
European Journal of EpidemiologyThe Generation R Study: design and cohort update 2010
1,042 Citations2010Vincent W. V. Jaddoe, Cornelia M. van Duijn +8 more
The Generation R Study is a population-based prospective cohort study designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood.
EpidemiologyMaternal body mass index and the risk of preeclampsia: a systematic overview.
692 Citations2003Tara O’Brien, Joel G. Ray +1 more
BMC Public HealthEffect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies
689 Citations2007Sohinee Bhattacharya, Doris M. Campbell +4 more
Increasing BMI is associated with increased incidence of pre-eclampsia, gestational hypertension, macrosomia, induction of labour and caesarean delivery; while underweight women had better pregnancy outcomes than women with normal BMI.
EpidemiologyMaternal Body Mass Index and the Risk of Preeclampsia: A Systematic Overview
635 Citations2003Tara E. O’Brien, Joel G. Ray +1 more
Most observational studies demonstrate a consistently strong positive association between maternal prepregnancy body mass index and the risk of preeclampsia, and increasing obesity in developed countries is likely to increase the occurrence of preeClampsia.
The Medical Journal of AustraliaThe prevalence and impact of overweight and obesity in an Australian obstetric population
630 Citations2006Leonie Callaway, Allan Chang +2 more
Assessment of the prevalence and impact of overweight and obesity in an Australian obstetric population finds that women are more likely to be overweight or obese than the general population.
EpidemiologyDoes Low Participation in Cohort Studies Induce Bias?
560 Citations2006Ellen A. Nøhr, Morten Frydenberg +2 more
The results are reassuring for studies based on the Danish cohort and similar cohorts of pregnant women and the methodology used to compute confidence intervals for the relative odds ratios performed well in the scenarios considered.
Annals of EpidemiologyThe Risk of Preeclampsia Rises with Increasing Prepregnancy Body Mass Index
402 Citations2005Lisa M. Bodnar, Roberta B. Ness +2 more
The results indicate that preeclampsia risk rises through most of the BMI distribution, and the dramatic elevation in overweight prevalence in the United States may increase preeClampsia incidence in the future.
BJOG An International Journal of Obstetrics & GynaecologyHyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study: associations with maternal body mass index
398 Citations2010HAPO Study Cooperative Research Group
Please cite this paper as: HAPO Study Cooperative Research Group Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) Study: associations with maternal body mass index.
BMC Pregnancy and ChildbirthThe risk of adverse pregnancy outcomes in women who are overweight or obese
383 Citations2010Chaturica Athukorala, Alice Rumbold +2 more
Obese women are at increased risk of gestational diabetes, pregnancy induced hypertension and pre-eclampsia, and babies of women who were obese were more likely to be large for gestational age and macrosomic compared with those of women with a normal BMI.
Journal of Obstetrics and Gynaecology CanadaThe Effect of Gestational Weight Gain by Body Mass Index on Maternal and Neonatal Outcomes
363 Citations2009Joan Crane, Joanne White +3 more
In women of normal weight, overweight, or obese, the rate of adverse outcome was lower in women with recommended weight gain than in those with excess weight gain, and the effects of gestational weight gain on pregnancy outcome depend on the woman's pre-pregnancy BMI.
Blood Pressure MonitoringValidation of the Omron HEM-907 device for blood pressure measurement
273 Citations2002Mohamed A. El Assaad, Jirar Topouchian +2 more
Obstetrics and GynecologyObesity and preeclampsia: the potential role of inflammation*1
262 Citations2001Myles Wolf
First-trimester C-reactive protein levels were significantly higher among women in whom preeclampsia subsequently developed compared with controls, and there was evidence of increased systemic inflammation in the first trimester.
European Journal of EpidemiologyThe Generation R Study Biobank: a resource for epidemiological studies in children and their parents
251 Citations2007Vincent W. V. Jaddoe, Rachel Bakker +10 more
Together with detailed phenotype measurements, these biological specimens form a unique resource for epidemiological studies focused on environmental exposures, genetic determinants and their interactions in relation to growth, health and development from fetal life onwards.
Maternal and Child Health JournalThe Implications of Maternal Overweight and Obesity on the Course of Pregnancy and Birth Outcomes
183 Citations2006Anna‐Maria Siega‐Riz, Anna‐Maria Siega‐Riz +1 more
The complications associated with maternal overweight and obesity including diabetes, pre-eclampsia, c-sections, and birth defects are provided, and updated information on the weight trends among women is presented.
Journal of Clinical EpidemiologyMedical record validation of maternally reported history of preeclampsia
158 Citations2010Marianne Coolman, Christianne J.M. de Groot +4 more
The validity of maternal-recall self-reported preeclampsia is moderate and might suggest a lack of accuracy in patient-doctor communication with regard to the diagnostic criteria of the disease.
American Journal of EpidemiologyInflammation and Triglycerides Partially Mediate the Effect of Prepregnancy Body Mass Index on the Risk of Preeclampsia
154 Citations2005Lisa M. Bodnar, Roberta B. Ness +2 more
It is suggested that approximately one third of the total effect of body mass index on preeclampsia risk is mediated through inflammation and triglyceride levels.
BJOG An International Journal of Obstetrics & GynaecologySuper‐obesity and risk for early and late pre‐eclampsia
146 Citations2010AK Mbah, JL Kornosky +7 more
This research highlights the need to understand more fully the role of adiposity in the development of pre‐eclampsia and its role in the risk of adverse events.
Early Human DevelopmentMaternal obesity and infant outcomes
139 Citations2010Rikke Ruager-Martin, Matthew J. Hyde +1 more
The direct and indirect impact of maternal obesity on the health of the baby is described and potential mechanisms drawing on data from human and animal studies, and on the outcomes of clinical interventional studies are reviewed.
International Journal of Gynecology & ObstetricsPrepregnancy body mass index, gestational weight gain, and pregnancy outcomes in China
116 Citations2009Zhen‐Yu Chen, Juan Du +5 more
To look for associations between pregnancy outcomes and prepregnancy body mass index and gestational weight gain among Han women from Shenyang province, China, a large number of women were recruited for this study.
BJOG An International Journal of Obstetrics & GynaecologyMaternal anthropometrics are associated with fetal size in different periods of pregnancy and at birth. The Generation R Study
116 Citations2009Lamise Ay, C J Kruithof +8 more
The associations of maternal anthropometrics with fetal weight measured in different periods of pregnancy and with birth outcomes were examined to examine the associations between these measurements and birth outcomes.
The Journal of Maternal-Fetal & Neonatal MedicineMaternal and perinatal outcome in obese pregnant patients
87 Citations2009Claire Schrauwers, Gus Dekker
These South Australian data from a socio-economically deprived area in Adelaide's Northern suburbs confirm that obesity during pregnancy represents a major risk for adverse outcome for patients with a whole spectrum of adverse pregnancy outcomes.
American Journal of PerinatologyExcessive Weight Gain among Obese Women and Pregnancy Outcomes
73 Citations2009Amy Flick, Kathleen Brookfield +4 more
Pregnancy outcomes in obese women with excessive weight gain during pregnancy are evaluated to reveal higher rates of preeclampsia, gestational diabetes, Cesarean deliveries, preterm deliveries, low birth weight, macrosomia, and NICU admission in class II and class III obese women when compared with class I women.
Paediatric and Perinatal EpidemiologyTrimester‐specific blood pressure levels in relation to maternal pre‐pregnancy body mass index
40 Citations2007Raymond Miller, Mary Lou Thompson +1 more
Elevated pregnancy BPs associated with maternal pre-gestational BMI are consistent with a large body of literature that documents increased pre-eclampsia risk among overweight and obese women.
Paediatric and Perinatal EpidemiologyModelling the association of blood pressure during pregnancy with gestational age and body mass index
36 Citations2009Mary Lou Thompson, Michelle A. Williams +1 more
Biological Research For NursingThe Effect of Obesity on Heart Rate (Heart Period) and Physiologic Parameters During Pregnancy
27 Citations2008Rebecca Jo Helmreich, Vanora Hundley +1 more
Autonomic responsiveness was found to be diminished in obese women with a BMI > 30 kg/m2 and in women with high risk for adverse pregnancy outcomes, which may indicate a maladaptive autonomic response that is imbalanced and disorganized and that reduces adaptation to environmental demands.
American Journal of Obstetrics and GynecologyBlood pressure patterns through consecutive pregnancies are influenced by body mass index
14 Citations2002Helena Strevens, Karl Kristensen +2 more
The interrelationship among blood pressure levels, parity, and body mass index in normal pregnancy resembles the situation in hypertensive pregnancies, which implies common adaptive mechanisms.
Journal of HypertensionWeight gain and hypertension
9 Citations2004David A. Calhoun, Guıdo Grassı
With conventional thinking, body weight gain causes hypertension, but a large body of evidence linking weight gain to increases in blood pressure suggests that up to 75% of the risk for hypertension is attributable to excess weight.
