Dehydroepiandrosterone: An anti‐obesity and anti‐carcinogenic agent
Nutrition and CancerPublished 1 January 1981
Arthur G. Schwartz, Gordon C. Hard, Laura L. Pashko, Magid Abou‐Gharbia, Daniel Swern
Citations63
SJR quartileQ2
SJR score0.68
SNIP0.63
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TL;DR
D dehydroepiandrosterone, an adrenal steroid found in subnormal levels in women predisposed to develop breast cancer, reduces weight gain without suppressing appetite and significantly inhibits the development of spontaneous breast cancer.
Abstract
Long-term treatment of female C3H-Avy/A (obese) and C3H-A/A (non-obese) mice with dehydroepiandrosterone, an adrenal steroid found in subnormal levels in women predisposed to develop breast cancer, reduces weight gain without suppressing appetite and significantly inhibits the development of spontaneous breast cancer. This steroid also antagonizes the capacity of the tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate, to stimulate 3H-thymidine incorporation in mouse epidermis and in a cultured rat kidney epithelial cell line.
Keywords
Medicine
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