Qualitative analysis of scopolamine-induced amnesia
PsychopharmacologyPublished 1 June 1981
Eric D. Caine, Herbert Weingartner, Christy L. Ludlow, Edward A. Cudahy, Susan Wehry
Citations188
SJR quartileQ1
SJR score1.16
SNIP0.97
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TL;DR
This study of scopolamine-induced memory deficits further defines those cognitive processes which are disrupted, as assessed with an auditory vigilance task, or initial signal detection.
Abstract
The neurochemistry of memory remains to be determined. Acetylcholine may be one of the neuotransmitters which mediates memory function, since the anticholinergic drug scopolamine produces amnesia in man. This study of scopolamine-induced memory deficits further defines those cognitive processes which are disrupted. The drug does not diminish attention, as assessed with an auditory vigilance task, or initial signal detection. More complex auditory decoding is affected, however. Scopolamine impairs aspects of initial memory acquisition (e. g., encoding and consolidation) and spontaneous memory retrieval. Retention is unaffected. Precise delineation of the neurochemistry of human memory will require comparative studies of amnesia-producing compounds, systematically examining the neuropsychological processes impaired by each.
Keywords
MedicineNeuroscience
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