Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor
NaturePublished 1 March 1987
Alun M. Davies, Christine E. Bandtlow, Rolf Heumann, Sigrun I. Korsching, Hermann Rohrer, H. Thoenen
Citations553
SJR quartileQ1
SJR score18.29
SNIP10.16
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TL;DR
It is shown that nerve growth factor (NGF) synthesis in developing skin begins with sensory innervation and that sensory neurons do not express NGF receptors until their fibres reach their cutaneous targets.
Abstract
We show that nerve growth factor (NGF) synthesis in developing skin begins with sensory innervation and that sensory neurons do not express NGF receptors until their fibres reach their cutaneous targets. Both cutaneous epithelium and mesenchyme synthesize NGF, the concentration of messenger RNA for NGF being higher in the more densely innervated epithelium.
Keywords
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