Extensions of the Allosteric Model for Haemoglobin

Numerical analysis yields a unique value for the allosteric constant showing that only the two state model can account for the behaviour of the protein.

Abstract

So far it has not been possible to distinguish experimentally between two possible models for cooperative ligand binding by haemoglobin. Numerical analysis, however, yields a unique value for the allosteric constant showing that only the two state model can account for the behaviour of the protein.