Endothelial lipase colon; a new member of the triglyceride lipase gene family
Current Opinion in LipidologyPublished 1 April 2000
Daniel J. Rader, Michael Jaye
Citations102
SJR quartileQ1
SJR score1.34
SNIP1.11
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TL;DR
The presence of key functional motifs, the endothelial synthesis, the enzymatic profile, and the in-vivo metabolic effects of endotheliallipase suggest that, like other members of this gene family, endothelial lipase may play a role in energy delivery to tissues and in modulating lipoprotein metabolism, and could impact on atherogenesis.
Abstract
The triglyceride lipase gene family plays a central role in intestinal lipid absorption, energy homeostasis, lipoprotein metabolism, and atherosclerosis. A new member of this gene family, termed endothelial lipase, was recently reported. The presence of key functional motifs, the endothelial synthesis, the enzymatic profile, and the in-vivo metabolic effects of endothelial lipase suggest that, like other members of this gene family, endothelial lipase may play a role in energy delivery to tissues and in modulating lipoprotein metabolism, and could impact on atherogenesis.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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