The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
Nature ImmunologyPublished 15 February 2007
Arlene H. Sharpe, E. John Wherry, Rafi Ahmed, Gordon J. Freeman
Citations1,496
SJR quartileQ1
SJR score10.39
SNIP3.81
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TL;DR
The functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses are examined and the therapeutic potential of manipulating this pathway is discussed.
Abstract
The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway.
Keywords
Immunology and MicrobiologyMedicine
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The ability of Pg lipopolysaccharide (LPS) to induce endotoxin tolerance and enhance the tolerogenic properties of APCs and up-regulated ILT-3 and B7-H1 expression is analyzed.
AutoimmunityAutoimmunity in coxsackievirus B3 induced myocarditis
40 Citations2006Sally A. Huber
Evidence for mechanisms of autoimmunity induction in coxsackievirus B3 induced myocarditis is discussed.
Investigative Ophthalmology & Visual ScienceCD4<sup>+</sup>PD-1<sup>+</sup>T Cells Acting as Regulatory Cells during the Induction of Anterior Chamber-Associated Immune Deviation
40 Citations2006Qianli Meng, Peizeng Yang +6 more
CD4+PD-1+ T cells from ACAID mice, as regulatory cells, are involved in the induction of antigen-specific suppression in association with enhanced expression of IL-10 in mice induced by intracameral injection of ovalbumin.
Clinical & Experimental ImmunologyImmunomodulation using the recombinant monoclonal human B7-DC cross-linking antibody rHIgM12
37 Citations2005Virginia P. Van Keulen, B Ciric +7 more
A monoclonal IgM antibody derived from this serum immunoglobulin that recapitulates each of these earlier observations, providing direct evidence that M protein from the Waldenstrom's patient mediates these potent immunomodulatory effects.
Autoimmunity ReviewsEpstein-Barr virus etiology in rheumatoid synovitis
35 Citations2004Shigemasa Sawada, Masami Takei
The Journal of Immunology<i>Chlamydia trachomatis</i> Infection Alters the Development of Memory CD8+ T Cells
25 Citations2006Wendy P. Loomis, Michael N. Starnbach
Chlamydia is able to alter the development of CD8+ T cell responses during both primary and secondary infection, perhaps accounting for the incomplete protection provided by prior Chlamydia infection.
The FASEB JournalRetraction
15 Citations2010Larry R. Pease
This analysis documents the ability of IgM Ab to activate a gene expression cascade leading to important biological changes in cellular function and provides mechanistic insight into the potent immunomodulatory properties attributed to this Ab.
The FASEB JournalInduction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC
14 Citations2006F. A. Blocki, S. Radhakrishnan +7 more
This analysis documents the ability of IgM Ab to activate a gene expression cascade leading to important biological changes in cellular function and provides mechanistic insight into the potent immunomodulatory properties attributed to this Ab.
PubMedT cell unresponsiveness in lepromatous leprosy.
9 Citations1993Thomas Kamradt
T lymphocytes from patients with lepromatous leprosy are anergic to M. leprae antigens, and recent insights from work on T cell recognition of antigen, cytokines, and T cell subsets have considerably enhanced the understanding of the immunopathology of le Promatous Leprosy.
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