Successful reversal of recalcitrant hepatic allograft rejection by photopheresis
Liver TransplantationPublished 1 September 2000Open access
Michael S. Lehrer, Eduardo Ruchelli, Kim M. Olthoff, Lars E. French, Alain H. Rook
Citations19
SJR quartileQ1
SJR score1.37
SNIP1.24
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Abstract
Extracorporeal photopheresis (ECP) is an immunologic modality that has shown efficacy in the treatment of clonal T-cell diseases, including Sézary syndrome and allograft rejection. In this case report, we expand on this observation to include recalcitrant hepatic allograft rejection. A 14-year-old boy with hepatic allograft rejection refractory to high-dose corticosteroid and lymphocytolytic therapy was treated with 4 sessions of ECP over a 6-week period. After 2 sessions, a liver biopsy showed complete reversal of acute cell-mediated rejection. No opportunistic infections or other adverse events were noted. Photopheresis appears to be a safe and effective modality for the treatment of refractory hepatic allograft rejection.
Keywords
Immunology and MicrobiologyMedicine
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