Prior strabismus protects kitten cortical neurons from the effects of monocular deprivation
Brain ResearchPublished 1 April 1981
Mike Mustari, Max S. Cynader
Citations20
SJR quartileQ2
SJR score0.85
SNIP0.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The effects of 8 days of monocular eyelid suture beginning at 45 days of age were compared in normal kittens and in kittens which had been made strabismic by surgery early in life.
Abstract
The effects of 8 days of monocular eyelid suture beginning at 45 days of age were compared in normal kittens and in kittens which had been made strabismic by surgery early in life. In both groups of animals, monocular deprivation increased the relative strength of inputs from the non-deprived eye at the cortical level, but this effect was clearly less pronounced in the strabismic animals. The reduced effect of monocular deprivation in strabismic animals was observed mainly in the cortical hemisphere contralateral to the deprived eye.
Keywords
Medicine
The Journal of PhysiologyThe period of susceptibility to the physiological effects of unilateral eye closure in kittens
3,029 Citations1970David H. Hubel, T. N. Wiesel
Kittens were visually deprived by suturing the lids of the right eye for various periods of time at different ages to study the effect of monocular eye closure on the number of cells that can be influenced by the previously closed eye.
The Journal of PhysiologyOcular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation.
701 Citations1978Carla J. Shatz, Michael P. Stryker
The findings suggest that the thalamocortical projection is physically rearranged as a consequence of monocular deprivation, as has been demonstrated for layer IVc of the monkey's visual cortex.
The Journal of PhysiologyReversal of the physiological effects of monocular deprivation in kittens: further evidence for a sensitive period
459 Citations1974Colin Blakemore, Richard C. Van Sluyters
It was confirmed that suturing the lids of one eye (monocular deprivation), until only 5 weeks of age, leaves virtually every neurone in the kitten's visual cortex entirely dominated by the other eye.
ScienceGlass Insulated Platinum Microelectrode
304 Citations1960Myron L. Wolbarsht, Edward F. MacNichol +1 more
Experimental Brain ResearchProfile of the sensitive period for monocular deprivation in kittens
280 Citations1980Carl R. Olson, R. D. Freeman
It was found that the effectiveness of monocular deprivation rose prior to postnatal day 28, remained high through day 48 and then subsided gradually, probably persisting at least through the end of the fourth postnatal month.
Brain ResearchThe distribution of afferents representing the right and left eyes in the cat's visual cortex
279 Citations1977Carla J. Shatz, Sar M +1 more
Transneuronal transport of radioactive materials following an intraocular injection of tritiated proline and fucose was used to identify the set of thalamocortical afferents representing the injected eye to demonstrate the presumed anatomical basis for ocular dominance columns in the cat's visual cortex.
The Journal of PhysiologyReversal of the physiological effects of monocular deprivation in the kitten's visual cortex.
182 Citations1976J. Anthony Movshon
It is suggested that the sensitive period for cortical binocular development consists of two phases, in which an increasing number of cortical neurones becomes fixed in their properties, while those that remain modifiable are as modifiable as they were at the end of the first phase.
Experimental Brain ResearchRecovery of function in cat visual cortex following prolonged deprivation
150 Citations1976M. Cynader, Nancy E.J. Berman +1 more
Evidence that cortical units retain plasticity long after the end of this period of deprivation is obtained, which shows that ocular alignment as well as cortical unit properties can remain plastic in the adult.
Brain ResearchPhysiological consequences of unilateral and bilateral eye closure in macaque monkeys: some further observations
109 Citations1975M.L.J. Crawford, Randolph Blake +2 more
The physiological effects reported herein could include some degree of recovery, as the monkeys studied were monocularly deprived by suturing the lids of the right eye for varying periods of time during infancy, and the sutured lids were reopened for periods up to 4 years before carrying out the neurophysiological experiment.
Brain ResearchPeriod of susceptibility of kitten visual cortex to the effects of monocular deprivation extends beyond six months of age
95 Citations1980M. Cynader, B.N. Timney +1 more
It is concluded that the sensitive period of the kitten visual cortex to the effects of monocular deprivation lasts at least twice as long as previously thought, to between 6 and 8 months of age.
NatureMonocular astigmatism effects on kitten visual cortex development
82 Citations1977Max S. Cynader, Donald E. Mitchell