Acute Systemic Effects of Cocaine in Man: A Controlled Study by Intranasal and Intravenous Routes

SciencePublished 18 February 1977

Richard B. Resnick, Richard S. Kestenbaum, Lee K. Schwartz

DOI10.1126/science.841307

Source URL

Citations254

SJR quartileQ1

SJR score10.42

SNIP6.62

TL;DR

The 100-milligram dose given intranasally and all of the doses given intravenously produced significant dose-related physiologic and subjective responses.

Abstract

Nineteen healthy volunteer subjects who regularly administered cocaine to themselves were given placebo and 10 and 25 milligrams of cocaine hydrochloride intravenously and intranasally. A dose of 100 milligrams of cocaine was administered only by the intranasal route. By this route 10 milligrams of cocaine produced no changes different from placebo, and 25 milligrams of cocaine produced physiologic changes only in systolic blood pressure. The 100-milligram dose given intranasally and all of the doses given intravenously produced significant dose-related physiologic and subjective responses.

Keywords

MedicineNeurosciencePharmacology, Toxicology and Pharmaceutics

Archives of General PsychiatryCardiovascular and Subjective Effects of Intravenous Cocaine Administration in Humans

329 Citations1976Marian W. Fischman

Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as dextroamphetamine sulfate, and generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings.

ScienceCocaine: Plasma Concentrations After Intranasal Application in Man

226 Citations1976Craig Van Dyke, P. G. Barash +2 more

In that residual cocaine was detectable on the nasal mucosa for 3 hours, continuous absorption secondary to its vasoconstrictive action might explain its persistence in the plasma.

American Journal of PsychiatryThe Effects of Cocaine on Depressed Patients

166 Citations1974Robert M. Post, Joel Kotin +1 more

While cocaine was capable of eliciting positive affective change in depressed patients, affective flooding and dysphoric components were often admixed, indicating that cocaine's effect in this context could not be classified simply as antidepressant.

JAMAExtent and Prevalence of Illicit Drug Use as Reported by 56,745 Students

63 Citations1971John T. Gossett, Jerry M. Lewis

A survey of all junior and senior high students in the nation's tenth largest public school system revealed that 28% reported experimentation with an illicit drug, 8% reported use more than ten times, and 4% reported frequent current use.

PsychopharmacologyThe Addiction Research Center Inventory: Appendix

44 Citations1963Harris E. Hill, Charles A. Haertzen +2 more

The present listing of items of the Addiction Research Center Inventory (ARCI) is presented as an appendix to papers that describe the development and initial use of this instrument which was devised for assessing subjective effects of drugs.