Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.
Cell RegulationPublished 1 November 1989Open access
Adam B. Glick, Kathleen C. Flanders, David Danielpour, Stuart H. Yuspa, Michael B. Sporn
Citations334
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TL;DR
The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.
Abstract
We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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