Emerging applications of metabolomics in drug discovery and precision medicine
Nature Reviews Drug DiscoveryPublished 11 March 2016
David S. Wishart
Citations1,430
SJR quartileQ1
SJR score30.51
SNIP23.21
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TL;DR
This Review discusses some of the latest technological advances in metabolomics, focusing on the application of metabolomics towards uncovering the underlying causes of complex diseases, the growing role of metabolites in drug discovery and its potential effect on precision medicine.
Abstract
Metabolomics is an emerging 'omics' science involving the comprehensive characterization of metabolites and metabolism in biological systems. Recent advances in metabolomics technologies are leading to a growing number of mainstream biomedical applications. In particular, metabolomics is increasingly being used to diagnose disease, understand disease mechanisms, identify novel drug targets, customize drug treatments and monitor therapeutic outcomes. This Review discusses some of the latest technological advances in metabolomics, focusing on the application of metabolomics towards uncovering the underlying causes of complex diseases (such as atherosclerosis, cancer and diabetes), the growing role of metabolomics in drug discovery and its potential effect on precision medicine.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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135 Citations2011Raphael Aggio, Silas G. Villas‐Bôas +1 more
The Metab R package is presented, designed to automate the pipeline for analysis of metabolomics GC-MS datasets processed by AMDIS, to create reliable datasets for further downstream analysis.
Journal of Proteome ResearchUntargeted Metabolomics as a Screening Tool for Estimating Compliance to a Dietary Pattern
133 Citations2014Maj-Britt Schmidt Andersen, Åsmund Rinnan +6 more
Untargeted metabolomics is a promising approach to develop compliance measures that cover the most important discriminant metabolites of complex diets, including citrus, cocoa-containing products, and fish.
Expert Opinion on Therapeutic TargetsTargeting enzyme inhibitors in drug discovery
130 Citations2007Robert A. Copeland, Mark R. Harpel +1 more
The authors describe the existing practices and future directions in drug discovery enzymology, with emphasis on how a detailed understanding of the catalytic mechanism of specific targets can be used to identify and optimize small-molecule compounds that interact with conformationally distinct forms of the enzyme, thus resulting in high potency, high selectivity inhibitors.
Molecular BioSystemsTargeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD
127 Citations2012Baljit K. Ubhi, Kian Kai Cheng +9 more
Results demonstrate that a metabolomic fingerprint has potential to stratify patients for the treatment of COPD and may provide a means of assessing response to therapy.
Journal of Nuclear MedicinePreparation and Characterization of l-[5-<sup>11</sup>C]-Glutamine for Metabolic Imaging of Tumors
123 Citations2011Wenchao Qü, Shunichi Oya +8 more
The results suggest that l-[5-11C]-glutamine might be useful for probing in vivo tumor metabolism in glutaminolytic tumors.
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