Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial
The LancetPublished 1 March 2000
Michael Eddleston, Senaka Rajapakse, Rajakanthan, S Jayalath, Lena Sjöström, Wijeyasingam Santharaj
Citations178
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
Anti-digoxin Fab fragments are a safe and effective treatment for serious cardiac arrhythmias induced by yellow oleander and their use in small rural hospitals in Sri Lanka should minimise costly transfer of patients and reduce the numbers of deaths.
Abstract
Anti-digoxin Fab fragments are a safe and effective treatment for serious cardiac arrhythmias induced by yellow oleander. Their use in small rural hospitals in Sri Lanka should minimise costly transfer of patients and reduce the numbers of deaths; however, further study will be required to confirm this reduction.
Keywords
Medicine
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Small children and domestic livestock are at increased risk of oleander poisoning, and experimental and established therapeutic measures involved in detoxification are discussed.
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In a fatal (cardiotoxic) case of oleander extract poisoning of a young female, ethanol extracts of blood and tissue homogenates were purified by lead acetate and oleandrin was extracted into chloroform.
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62 Citations1979Douglas V. Shaw, John Pearn
A seven‐year total population survey from south‐east Queensland has revealed that, in practice, the rate of clinical poisoning due to oleander is inconsequential, and mortality is negligible.
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