A new method for rapid screening of minor tranquillizers in mice

European Journal of PharmacologyPublished 1 September 1968

J R Boissier, Pierre Simon, C Aron

DOI10.1016/0014-2999(68)90170-2

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Citations124

SJR quartileQ1

SJR score1.20

SNIP0.98

TL;DR

It was found that, among the various psychotropic drugs studied, only chlordiazepoxide, diazepam, meprobamate and phenobarbital increased the number of punished crossings whereas imorphine decreased it.

Abstract

J.R.BOISSIER, P.SIMON and C.ARON, A new method for rapid screening of minor tranquillizers in mice, European J. Pharmacol. 4 (1968) 145–151. The conditioned suppression of simple ongoing behavior has been described. Mice were punished with an electric shock each time they crossed from one part of the apparatus to another. The influence of minor tranquillizers, phenobarbital, neuroleptics, d-amphetamine, antidepressantsand morphine on this behavior was studied. It was found that, among the various psychotropic drugs studied, only chlordiazepoxide, diazepam, meprobamate and phenobarbital increased the number of punished crossings whereas imorphine decreased it. This method is very rapid and seems to lend itself very well to the preliminary study of drugs in which a tranquillizing action is anticipated.

Keywords

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