Regeneration after acute tubular necrosis

A 44 year-old woman took six mercuric bichloride tablets and entered the hospital with nausea and abdominal cramps three hours later and died on the 29th day after clearances of inulin, creatinine and PAH were infinitesimal on six occasions.

Abstract

A 44 year-old woman took six mercuric bichloride tablets (3.0 gm.) and entered the hospital with nausea and abdominal cramps three hours later.Her blood pressure was 86/60.Five hours after the ingestion of the poison, BAL treatment was begun and she was given 2 cc.every four hours for six days, and then 1 cc, every 12 hours for five days.During the first 42 hours the patient had diarrhea, vomited and suffered abdominal cramps.Fifty cc. of urine were passed in the first 24 hours, then none for five days.The urinary output rose slowly for six days to 935 cc. and then fell to an average of 120 cc. until death.The NPN on the second day was 53 mg. per cent rising to 450 on the 28th day.On the 29th day she died, clearances of inulin, creatinine and PAH were infinitesimal on six occasions.