Catecholamines and Diagnoses in Children
Journal of the American Academy of Child & Adolescent PsychiatryPublished 1 March 1990
Graham A. Rogeness, Martin A. Javors, James W. Maas, Carlos A. Macedo
Citations50
SJR quartileQ1
SJR score3.00
SNIP2.88
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TL;DR
Comparisons between clinical and biological measures within each of the D beta H groups were consistent with the hypothesized relationship between NA function, CDU, and anxiety/depressive disorder.
Abstract
Theoretically, noradrenergic (NA) function may be lower in subjects with undersocialized conduct disorder (CDU) and higher in subjects with anxiety/depressive disorder. To test this hypothesis, diagnostic and 24-hour urine catecholamine measures were compared between subjects with plasma dopamine-beta-hydroxylase (D beta H) activities less than 6 mumoles/min/L (low D beta H group) and greater than 15 mumoles/min/L (high D beta H group). Several measures relating to norepinephrine metabolism were lower in the low D beta H group, and the low D beta H group had more diagnoses of CDU and fewer anxiety and depressive disorder diagnoses. Comparisons between clinical and biological measures within each of the D beta H groups were also consistent with the hypothesized relationship between NA function, CDU, and anxiety/depressive disorder.
Keywords
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