Breast milk and defence against infection in the newborn.
Archives of Disease in ChildhoodPublished 1 December 1972Open access
Lars Hanson, Jan Winberg
Citations234
SJR quartileQ1
SJR score0.97
SNIP1.16
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TL;DR
The value of breast Milk in defense against infection in the newborn infant is examined and several observations suggest a protective role of breast milk against enteric infections.
Keywords
Biochemistry, Genetics and Molecular BiologyMedicineNursing
The Journal of Experimental MedicineCHARACTERISTICS OF AN IMMUNE SYSTEM COMMON TO CERTAIN EXTERNAL SECRETIONS
1,005 Citations1965Thomas B. Tomasi, Eng M. Tan +2 more
The γ1A present in saliva and colostrum exists largely in the form of higher polymers, the major component of which has a sedimentation coefficient of 11S, and its properties including the local production of a distinctive type of antibody separate it from the "systemic" system responsible for the production of circulating antibody.
BMJIron-binding Proteins in Milk and Resistance to Escherichia coli Infection in Infants
658 Citations1972J. J. Bullen, H. J. Rogers +1 more
It seems that iron-binding proteins in milk may play an important part in resistance to infantile enteritis caused by E. coli.
The LancetDOES BREAST MILK PROTECT AGAINST SEPTICÆMIA IN THE NEWBORN ?
514 Citations1971Jan Winberg, G. Wessner
It is suggested that breast milk may offer a certain immunity to the newborn against early infections by bacteria of enteric origin.
The Journal of Infectious DiseasesInhibition of Growth of Candida albicans by Iron-Unsaturated Lactoferrin: Relation to Host-Defense Mechanisms in Chronic Mucocutaneous Candidiasis
196 Citations1971Charles H. Kirkpatrick, I. Green +2 more
Since iron-binding proteins in serum and external secretions inhibit growth of certain microorganisms, the effect of lactoferrin on growth of Candida albicans was determined and it was found that the iron-unsaturated protein markedly impaired replication of the yeast.
Pediatric ResearchThe Cells of Human Colostrum. I. In Vitro Studies of Morphology and Functions
191 Citations1968C. Wayne Smith, Armond S. Goldman
Observations indicate that immunologically active cells are normal constituents of human colostrum and the possibility is advanced that these cells may influence the host response of the neonatal recipient.
BMJResistance of the Breast-fed Infant to Gastroenteritis
184 Citations1971C. L. Bullen, A. T. Willis
In-vitro studies of breast and cow's milk preparations, and of the faeces from breast-fed and bottle-fed infants, a number of factors seemed likely to influence the production and maintenance of a lactobacillary flora and low pH in the faes of newborn infants, mainly attributable to the nature of the feed.
Archives of Pediatrics and Adolescent MedicineChanges in the Pattern of Neonatal Septicemia and Meningitis
130 Citations1966George H. McCracken
An 11-year experience with neonatal septicemia and meningitis at the New York Hospital is reviewed, with particular attention on the changing pattern of infection and etiological agents, the predisposing conditions to neonatal infection, and problems in diagnosis and therapy.
Acta PaediatricaFamilial Dysplasia of Kidneys, Liver and Pancreas A Probably Genetically Determined Syndrome
123 Citations1959Kjell Aas, VERA OLDFELT +1 more
PEDIATRICSTHE RELATIONSHIP OF MATERNAL ANTIBODY, BREAST FEEDING, AND AGE TO THE SUSCEPTIBILITY OF NEWBORN INFANTS TO INFECTION WITH ATTENUATED POLIOVIRUSES
95 Citations1964Robert J. Warren, Martha L. Lepow +2 more
Over 1,000 infants were fed attenuated polioviruses during the first 3 months of life and susceptibility to infection with these agents was shown to be related to dose of virus, titer of maternal antibody, method of milk feeding, and age at vaccination.
PubMedBacterial and viral coproantibodies in breast-fed infants.
92 Citations1967Jean F. Kenny, Mary Boesman +1 more
The LancetINFANT MORBIDITY AND MORTALITY A STUDY OF 3266 INFANTS
88 Citations1951Margaret Robinson
No definite conclusions could be drawn regarding the influence of social class on infant disease although infant mortality was higher among the lower classes, and the chance of infection was found to be higher as family size increased.
Experimental Biology and MedicineImmune Globulin Levels in Colostrum and Breast Milk, and Serum From Fomula- and Breast-Fed Newborns.
84 Citations1966A. J. Ammann, E.R. Stiehm
Immune globulin levels in colostrum and breast milk determined during the first 4 days of nursing show high levels in Colostrum, especially of γA globulin, followed by a rapid decline with transition to mature breast milk, which would indicate failure of intact immune globulins to be absorbed by the gastrointestinal tract in sufficient amounts to affect immune Globulin levels during this period of life.
PEDIATRICSBACTERIAL AND VIRAL COPROANTIBODIES IN BREAST-FED INFANTS
81 Citations1967Jean F. Kenny, Mary Boesman +1 more
Stools of newborn breast-fed infants may contain significant amounts of hemagglutinating antibody to enteropathogenic E. coli and neutralizing antibody to polioviruses and similar ratios of stool:milk activity were found for paired specimens obtained during the second and third postpartum months.
BMJProgestin therapy of breast cancer: comparison of agents.
77 Citations1967Basil A. Stoll
It is suggested that the metabolism of different progestins might be investigated in breast cancer patients by the administration of radioactively tagged progestin derivatives.
Pediatric ResearchThe Cells of Human Colostrum II. Synthesis of IgA and β1c
71 Citations1970Gisela Jorge Murillo, Armond S. Goldman
The Journal of Infectious DiseasesThe Antimicrobial Activity of Human Colostral Antibody in the Newborn
63 Citations1971J. Gabriel Michael, RAYMOND RINGENBACK +1 more
Bacterial counts in the stools of breast-fed infants were found to differ quantitatively and qualitatively from those of bottle-fed newborns, and existence of a direct correlation between the concentrations of immunoglobulins and reduction of coliform bacteria in theStools of breastfeeding newborns was observed.
Archives of Pediatrics and Adolescent MedicineShigella Infection in Breast-Fed Guatemalan Indian Neonates
61 Citations1969Leonardo Mata
The authors want to advance observations on Shigella infections in neonates from a semiprimitive Mayan village of Guatemala, because the behavior of infections in these infants departs from that described by the American authors.
Journal of Surgical OncologyColostral leukocytes
53 Citations1970John A. Mohr, Richard K. Le Leu +1 more
The finding that these leukocytes are in relatively large numbers and possess phagocytic activity supports the concept that this is a naturally occurring in vivo phenomenon and that these cells may protect the breast against invading microorganisms.
American journal of diseases of childrenNeonatal Shigellosis
36 Citations1967Kenneth C. Haltalin
This paper summarizes the eight previously reported cases and the 16 cases seen at Children's Medical Center and Parkland Memorial Hospital in Dallas, presenting four cases, which developed while the infants were in the nursery, and four cases with Onset in the Hospital Nursery Case.
The Journal of PediatricsThe acquisition of fecal flora by infants from their mothers during birth
32 Citations1959Florence E. Gareau, Donald C. Mackel +3 more
The presence of organisms of the Klebsiella-Cloacae group in only 4 of the 18 specimens obtained from the infants housed in the new, modern unit, and in 38 of the 39 specimens obtained with less adequate facilities, suggests the environment as an important source of these bacteria.
The Journal of PediatricsMeningitis and septicemia due to Shigellae in a newborn infant
32 Citations1967Charles Whitfield, Jennifer Humphries
D. R. P., a Caucasian male infant, weighing 3.4 kilograms appeared normal at birth except for what one author considered an abnormal cry, and appeared to develop jaundice during the period of observation.
PubMedPneumococcal antibodies in IgA of serum and external secretions.
29 Citations1970R. P. Mouton, J. W. Stoop +2 more
An indirect immuno-fluorescent method is described for the detection of group and type specific antibodies against pneumococci and the localization of these antibodies in the various immunoglobulin classes can be established by this method.
American Journal of Tropical Medicine and HygieneStudies in Shigellosis. V. The Relationship of Age to the Incidence of Shigella Infections in Egyptian Children, with Special Reference to Shigellosis in the Newborn and in Infants in the First Six Months of Life
26 Citations1956Thomas M. Floyd, Ann Higgins +1 more
Egyptian village children in the first six months of life, while exposed to a highly endemic environment and experiencing a higher incidence of diarrheal disease, were less frequently infected with Shigella organisms than were older children.
BMJBacteriology of Throat and Rectum of Infants
20 Citations1949A. M. McFarlan, Patricia Crone +1 more
The Journal of PediatricsShigellae with transferable drug resistance: Outbreak in a nursery for premature infants
14 Citations1967Theodore Salzman, Charles D. Scher +1 more
A strain of Shigella sonnei causing an outbreak of shigellosis in a nursery for premature infants was resistant to tetracycline, chloramphenicol, streptomycin, and sulfonamides and transferable by an R factor.
Acta PaediatricaBreast or Cow's Milk as Infant Food Discussion on the Methods of Comparison
14 Citations1954G. Sydow, NILS FAXÉN
A very limited investigation of this kind is described, where the number of days with a rise in temperature was found to be considerably higher in the cow's milk group than in the breast‐milk group.
Scottish Medical JournalColiform Bacteraemia in Infants
6 Citations1969Nancy K. Conn
There has been an increase during these years particularly in neonatal infants and children born either prematurely or as a multiple birth and those with congenital malformations showed a predisposition to this form of infection.