CORTICOTROPIN-RELEASING FACTOR (CRF): CENTRAL EFFECTS ON MEAN ARTERIAL PRESSURE AND HEART RATE IN RATS.
EndocrinologyPublished 1 June 1982
Laurel A. Fisher, EAN JRIVIER, Catherine Rivier, Joachim Spiess, Wylie Vale, Marvin R. Brown
Citations262
SJR quartileQ1
SJR score1.31
SNIP1.01
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The results suggest that CRF acts within the brain to stimulate sympathetic nervous activity which in turn influences cardiovascular function.
Abstract
Intracerebroventricular administration of corticotropin-releasing factor (CRF) produces elevations in mean arterial pressure and heart rate in conscious freely-moving rats. Pretreatment with the ganglionic blocker, chlorisondamine, completely prevents the CRF-induced cardiovascular changes. These results suggest that CRF acts within the brain to stimulate sympathetic nervous activity which in turn influences cardiovascular function.
Keywords
MedicineNeuroscience
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