Regional Cerebral Blood Flow Estimated by <sup>133</sup> Xenon Inhalation
StrokePublished 1 May 1975Open access
Walter D. Obrist, Howard Thompson, HSIOH SHAN WANG, William E. Wilkinson
Citations858
SJR quartileQ1
SJR score2.66
SNIP2.52
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TL;DR
A method is described for estimating the clearance rate and fractional blood flow of the fast (gray matter) compartment of the brain from the first ten minutes of 122 XE clearance curves, following a one-minute inhalation.
Abstract
A method is described for estimating the clearance rate and fractional blood flow of the fast (gray matter) compartment of the brain from the first ten minutes of 122 XE clearance curves, following a one-minute inhalation. Computer-simulated data were used to test the adequacy of the two-compartmental model employed, and to evaluate the stability of the parameters in the presence of random noise. A comparison was made between this approach and the previously reported three-compartmental analysis. Regional cerbral blood flow data were obtained on 48 young control subjects and 20 elderly demented patients. Hemispheral, regional, and test-retest variations were determined, as well as differences between the groups.
Keywords
MedicineNeuroscience
Circulation ResearchDetermination of Regional Cerebral Blood Flow by Inhalation of 133-Xenon
385 Citations1967Walter D. Obrist, Howard Thompson +2 more
Comparison of results based on expired air and arterial sampling suggested that end-expiratory air is a reasonable substitute for arterial blood.
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Bilateral rCBF measurements made by the 133Xe inhalation technique during mental activities supposed to engage the hemispheres selectively can be used with advantage in the study of lateralization of mental functions in the human brain.
Physics in Medicine and BiologyThe Partition of Trace Amounts of Xenon Between Human Blood and Brain Tissues at 37°C
177 Citations1965N. Veall, B. L. Mallett
The relative solubilities of trace amounts of 133Xe at 37? C in human plasma, red blood cells, grey and white matter of the brain, and in homogenized whole brain have been determined and it is estimated that the human brain consists of 60?3?6?3% grey matter and the remainder white matter.
Journal of Neurology Neurosurgery & PsychiatryRegional blood flow in the normal cerebral hemisphere.
142 Citations1969Iain Wilkinson, J. W. D. Bull +4 more
The clearance-of 133Xenon from the cerebral hemisphere after a single intracarotid injection has been observed by 16 regional detectors and its value as a rapid assessment of flow in the resting state, and during short-lived physiological test situations, has been stressed.
Circulation ResearchValidity of the Xenon <sup>133</sup> Method for Measurement of Muscle Blood Flow Evaluated by Simultaneous Venous Occlusion Plethysmography
74 Citations1965Niels A. Lassen, I. F. Lindbjerg +1 more
The results obtained indicate that the Xe133 modification of Kety's local clearance method for measurement of muscular blood flow in man is essentially valid.
Archives of NeurologyRegional Cerebral Blood Flow in Man
42 Citations1969E. James Potchen
This technique is currently advocated as the most physiologic means to measure regional blood flow and, therefore, is assuming increasing importance as an adjunct to carotid arteriography.
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Acta Neurologica ScandinavicaTHE EFFECT OF SEROTONIN ON CEREBRAL AND EXTRACEREBRAL BLOOD FLOW WITH POSSIBLE IMPLICATIONS IN MIGRAINE
40 Citations2009V. D. Deshmukh, A. M. Harper
The blood flow through the external carotid artery and the temporal muscle increased by several hundred per cent and the cerebral blood flow was reduced by 17 % at normocapnia but by twice this figure at hypercapnia.
The 133Xe Inhalation Method: Assessment of rCBF in Carotid Endarterectomy
24 Citations1975Walter D. Obrist, Donald Silver +4 more
The present paper describes the application of the noninvasive 133Xe inhalation method to patients undergoing unilateral internal carotid endarterectomy.
Further Studies on Exponential Models of Cerebral Clearance Curves
24 Citations1969Martin Reivich, Robert R. Slater +1 more
The purpose of the present communication is to further evaluate this bimodal Gaussian model and to compare it with the two compartment model using cerebral clearance curves synthetized from regional cerebral blood flow data obtained in cats.
Journal of GerontologyEffects of Hyperbaric Oxygen on Behavioral and Physiological Measures in Elderly Demented Patients
22 Citations1976L. W. Thompson, Gail C. Davis +2 more
It is suggested that HBO has no therapeutic effect in patients with moderate to severe dementia with cerebrovascular disease and cortical atrophy.
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19 Citations1974Noel Rao, ZENAB ALI +2 more
The 133Xenon inhalation method of measuring regional cerebral blood flow was applied in serial studies comprising 100 measurements in 57 cases of acute hemiparesis and hemiplegia presumed due to arterial occlusion, demonstrating the feasibility of applying this method for serial regional cerebralBlood flow measurements in most Cases of acute stroke.
StrokeNewer Techniques of Cerebral Blood Flow Measurement
16 Citations1972Jerome B. Posner
There has been considerable enhancement of the understanding of the pathophysiology of cerebral circulation, particularly in the areas of brain injury and disordered systemic metabolism, but the clinical usefulness of the test at the present time is limited.
Journal of Neurology Neurosurgery & PsychiatryEffect of changes in cerebral blood flow on proportion of high and low flow tissue in the brain
14 Citations1974L. D. Iliff, E. Zilkha +6 more
Regional cerebral blood flow was measured in 11 patients with cerebrovascular disease and showed that in areas where blood flow through grey matter changed most the proportion of fast clearing tissue changed least and vice versa, and a hypothesis has been proposed to explain this phenomenon.
British Journal of AnaesthesiaA STUDY OF THE ARTERIAL CLEARANCE OF XENON 133 IN MAN
10 Citations1965William H. Isbister, P F Schofield +1 more
Arterial xenon 133 concentrations have been measured after inhalation of the isotope in anaesthetized and conscious human patients and the significance of these findings was discussed with particular reference to the determination of cerebral blood flow.
Pitfalls in the Interpretation of Xenon CBF Studies in Head-Injured Patients
9 Citations1975Derek A. Bruce, Hart Schutz +2 more
The calculation of CBF by the biexponential analysis of 133Xe clearance from the brain has been shown to satisfactorily depict flow through the gray and white matter of the brain and to give relative weights for each compartment.
Japanese Heart JournalExternal Measurement of Regional Cerebral Blood Flow in Man by Common Carotid Arterial Injection of Radioactive Krypton-85 Saline Solution
7 Citations1968Hideo UEDA, Shuichi Hatano +2 more
Cerebral blood flow was decreased in cases with cerebrovascular diseases and this is proved to be the result of decrease of both blood flow and relative weight of grey matter.