Commonly deleted regions on the long arm of chromosome 21 in differentiated adenocarcinoma of the stomach
Genes Chromosomes and CancerPublished 1 April 1997
Ken Sakata, Gen Tamura, Satoshi Nishizuka, Chihaya Maesawa, Yasushi Suzuki, Takeshi Iwaya
Citations56
SJR quartileQ1
SJR score1.36
SNIP1.15
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
Abstract
During an allelotype analysis of differentiated adenocarcinoma of the stomach, we observed frequent loss of heterozygosity (LOH) on several chromosomes including the long arm of chromosome 21 (21q). Therefore, we analyzed DNA isolated from 45 tumors for LOH at 10 loci on 21q by using polymorphic microsatellite markers. In 20 (44%) of 45 tumors, we detected LOH at single or multiple loci on 21q. Deletion mapping of these 20 tumors revealed two separate commonly deleted regions. Our findings suggest that 21q contains at least two potential tumor suppressor genes which play crucial roles in the development of differentiated adenocarcinoma of the stomach.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
Annual Review of BiochemistryINTERFERONS AND THEIR ACTIONS
1,828 Citations1987Sidney Pestka, Jerome A. Langer +2 more
One that the authors will refer to break the boredom in reading is choosing interferons and their actions as the reading material.
Proceedings of the National Academy of Sciencest(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
884 Citations1991H Miyoshi, K Shimizu +4 more
Cl cloning of a gene on chromosome 21 that was found to be rearranged in the leukemic cell DNAs from t(8;21) AML patients indicates that the AML1 gene may be involved in neoplastic transformation of AML with the t(7;21;q22) translocation.
Proceedings of the National Academy of SciencesCytokine therapeutics: lessons from interferonalpha.
705 Citations1994Jordan U. Gutterman
The principles established with IFN-alpha serve as a paradigm for future development of natural proteins for human disease, affecting cellular communication and signal transduction pathways as well as immunological control.
CellGenetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA
582 Citations1990Gilles Uzé, Georges Lutfalla +1 more
A cDNA coding for the human interferon alpha receptor has been cloned using a gene transfer approach and mouse cells expressing the cDNA become sensitive to the antiviral activity of and express binding sites for human interFERon alpha, demonstrating that the cloned cDNA encodes a functional human interferential receptor.
CellIdentification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins
514 Citations1994Gaston Habets, Ellen H.M. Scholtes +5 more
Using proviral tagging in combination with in vitro selection for invasiveness, a gene is identified, designated Tiam-1, that affects invasion and harbors a Dbl- and Pleckstrin-homologous domain that it shares with GDP-GTP exchangers for Rho-like proteins that have been implicated in cytoskeletal organization.
PubMedGenetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.
435 Citations1993Hye-Jung Han, Akio Yanagisawa +3 more
It is suggested that genetic instability is likely to play an important role in development of pancreatic and gastric cancers, particularly poorly differentiated adenocarcinomas.
PubMedAllelotype of head and neck squamous cell carcinoma.
342 Citations1994Homaira Nawroz, P. Van Der Riet +4 more
A high frequency of allelic loss in these advanced stage neoplasms suggests multiple genetic steps in the progression of head and neck cancer and identifies several putative tumor suppressor loci on affected chromosomes.
PubMedAllelotype of human bladder cancer.
263 Citations1994Margaret A. Knowles, PA Elder +4 more
A significant association was found between increased fractional allele loss and higher tumor grade and an association was also found between LOH of chromosomes 8p and 9q and values for fractional allelic loss > or = the median value.
PubMedHuman epithelial ovarian cancer allelotype.
242 Citations1993William A. Cliby, S Ritland +6 more
These tumors suggest that at least 2 regions of chromosome 6 are important for ovarian epithelial carcinogenesis and one region appears to be on distal 6q and a second region is near the centromere of chromosomes 6 proximal to the HLA locus.
Human Molecular GeneticsSomatic mutation of the <i>APC</i> gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma
231 Citations1992Shuichi Nakatsuru, Akio Yanagisawa +5 more
The results suggest that inactivation of APC plays a role in development of some gastric cancers, particularly very well differentiated adenocarcinomas and signet-ring cell carcinomas.
PubMedDetection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.
228 Citations1991G Tamura, Toshimasa Kihana +4 more
The findings suggest that p53 gene mutations are related to DNA ploidy alterations as relatively late events of carcinogenesis in gastric cancer.
PubMedThe APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.
227 Citations1992Akira Horii, Shuichi Nakatsuru +6 more
PubMedFrequent loss of heterozygosity at the DCC locus in gastric cancer.
207 Citations1992S. Uchino, Hitoshi Tsuda +7 more
LOH on chromosome 18q was frequent irrespective of the depth of tumor invasion, whereas the incidence of Loh on chromosome 17p was higher in the cases in which the tumor invaded beyond the muscularis propria than in those in which tumor invasion was limited to the submucosa and musculari propria.
PubMedMicrosatellite instability in the progression of gastric carcinoma.
206 Citations1994Ja‐Mun Chong, Masashi Fukayama +6 more
PubMedAllelotype of pancreatic adenocarcinoma.
200 Citations1994Albert Seymour, Ralph H. Hruban +6 more
The first allelotype of pancreatic adenocarcinoma is assembled, a survey for allelic loss among each chromosomal arm, using seven cryostat-dissected neoplasms, with a value similar to that seen previously in colorectal carcinoma.
PubMedMicrosatellite instability occurs frequently in human gastric carcinoma.
198 Citations1994Mun Gan Rhyu, Won Sang Park +1 more
Results demonstrate that microsatellite instability is not limited to colorectal carcinoma, but also occurs frequently in another cancer, that of the stomach, and is probably a late event, developing only rarely in premalignant dysplastic lesions.
PubMedAllelotype analysis in osteosarcomas: frequent allele loss on 3q, 13q, 17p, and 18q.
162 Citations1992Toshikazu Yamaguchi, Junya Toguchida +8 more
Although no definite association of fractional allelic loss value to clinical prognosis of each case was found in osteosarcoma, tumors with 17p loss were more prone to the early onset of lung metastasis than tumors without 17P loss, indicating that allele loss on chromosome 17p can be a useful measure of prognosis.
PubMedDifference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung.
157 Citations1994S Sato, Yoshimasa Nakamura +1 more
It is suggested that more genetic changes accumulate during tumorigenesis in squamous cell carcinomas than in adenocarcinomas and that unidentified tumor suppressor genes exist on chromosome 9q for squamouscell carcinoma and on chromosome 8q for adenOCarcinoma of the lung.
Lung CancerAllelotype of non-small cell lung carcinoma - Comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma
146 Citations1993Eiju Tsuchiya
The results implicate the presence of several tumor suppressor genes associated with development and/or progression of non-small cell lung carcinomas with correlation to fractional allelic loss and pathohistological grade.
Genes Chromosomes and CancerAllelotype study of esophageal carcinoma
109 Citations1994Takahisa Aoki, Takahiro Mori +4 more
Although allelic loss at the APC locus is frequent in squamous cell carcinomas of the esophagus, it is likely that a gene on 5q other than APC is involved in esophageal tumorigenesis.
PubMedTwo distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach.
105 Citations1996G Tamura, S Ogasawara +7 more
At least two putative tumor suppressor genes, which play a crucial role in the genesis of differentiated adenocarcinoma of the stomach and are distinct from the APC gene, lie on 5q, including the D5S428 locus and the interferon regulatory factor-1 (IRF-1) locus.
The Journal of PathologyALLELOTYPE OF ADENOMA AND DIFFERENTIATED ADENOCARCINOMA OF THE STOMACH
101 Citations1996Gen Tamura, Ken Sakata +6 more
Observations suggest that the adenoma–carcinoma sequence is not a major pathway in gastric tumourigenesis.
Journal of Biological ChemistryThe structure of the human interferon alpha/beta receptor gene.
100 Citations1992Georges Lutfalla, Katheleen Gardiner +3 more
The exon structure of the IFNAR gene and of that of the available genes for the receptors of the cytokine/growth hormone/prolactin/interferon receptor family have been compared with the predictions for the secondary structure of those receptors and a common origin is postulated.
Proceedings of the National Academy of SciencesComprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes.
93 Citations1995Catherine Thrash-Bingham, Richard E. Greenberg +7 more
LOH for 6q, 8p, 9pq, and 14q is also distinctly elevated for both nonpapillary as well as papillary tumors and suggest that many of the tumor suppressor loci involved may be common to the etiology of both forms of kidney cancer.
Genes Chromosomes and CancerAllelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: Frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p
91 Citations1994Michael H. Jones, Yusuke Nakamura +4 more
High frequencies of allelic loss found at loci on 3p (71%), 9q (38%).
PubMedMicrosatellite alterations in adenoma and differentiated adenocarcinoma of the stomach.
91 Citations1995Gen Tamura, Ken Sakata +8 more
The results suggest that the adenoma-carcinoma sequence is relatively rare in gastric carcinogenesis, and that the majority of differentiated adenocarcinomas of the stomach may develop through a de novo pathway.
Japanese Journal of Cancer ResearchPoint Mutation of c‐Ki‐ras Oncogene in Gastric Adenoma and Adenocarcinoma with Tubular Differentiation
76 Citations1991Toshimasa Kihana, Hitoshi Tsuda +5 more
The results suggest that the genetic mechanism of carcinogenesis differs between the differentiated type and the undifferentiated type of gastric adenocarcinoma, and also that c‐Ki‐ros activation is possibly involved in a relatively early step of the “adenoma‐cARCinoma sequence,” which leads to the development of a portion of differentiated adenOCarcinomas in the stomach.
Genes Chromosomes and CancerAllelic imbalance in gastric cancer: An affected site on chromosome arm 3p
73 Citations1995Barbara Schneider, Donald R. Pulitzer +7 more
An allelotype study on 78 gastric adenocarcinomas from a population composed largely of Texan Hispanics and Anglos indicates that a tumor suppressor gene on chromosome arm 3p is involved in the development of a subset of gastric cancers.
PubMedEvidence for limited molecular genetic heterogeneity as defined by allelotyping and clonal analysis in nine metastatic breast carcinomas.
42 Citations1993Bert A. Bonsing, Peter Devilee +4 more
An advanced primary breast carcinoma consists of a clonal tumor cell population with an established complement of allelic imbalances in all parts of the primary tumor and in the related lymph node metastases, which in turn probably precedes metastasis.
Journal of Biological ChemistryA gene on human chromosome 21 located in the region 21q22.2 to 21q22.3 encodes a factor necessary for signal transduction and antiviral response to type I interferons.
38 Citations1994Paul J. Hertzog, Seung Yong Hwang +4 more
It is demonstrated that a gene(s) located in the region 21q22.2-3 encodes a factor which is necessary for signaling but does not influence ligand binding, and this factor is not the cofactor required for IFN gamma signaling which is located inThe region 21p to 21q 22.1(2).
Journal of Interferon ResearchAssignment of the Human Interferon-α Receptor Gene to Chromosome 21q22.1 by <i>In Situ</i> Hybridization
31 Citations1990Georges Lutfalla, Nathalie Roëckel +3 more
The present report confirms the assignment of the human interferon-alpha receptor gene to the long arm of human chromosome 21 and refines the mapping to the 21q22.1 band, using a cDNA probe for the human IFN AR gene and in situ hybridization to metaphase chromosomes.
Cytogenetics and Cell GeneticsThe invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse Chromosome 16
18 Citations2008Gaston Habets, Rob A. van der Kammen +5 more
The murine invasion-inducing Tiam1 gene maps to the distal end of chromosome 16, 3.8 cM centromeric of the Ets2 gene, and TIAM1, the human homolog of Tiam 1, maps toThe syntenic region (q22) on human chromosome 21.