HIV neuropathy natural history cohort study
NeurologyPublished 12 June 2006
David M. Simpson, Douglas Kitch, Scott Evans, Justin C. McArthur, David M. Asmuth, Bruce A. Cohen
Citations175
SJR quartileQ1
SJR score2.40
SNIP1.82
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TL;DR
In this cohort of advanced HIV infection–infected subjects, distal sensory polyneuropathy was common and relatively stable over 48 weeks, and previously established risk factors, including CD4 cell count, plasma HIV RNA, and use of dideoxynucleoside antiretrovirals were not predictive of the progression of DSP.
Abstract
In this cohort of advanced human immunodeficiency virus (HIV)-infected subjects, distal sensory polyneuropathy was common and relatively stable over 48 weeks. Previously established risk factors, including CD4 cell count, plasma HIV RNA, and use of dideoxynucleoside antiretrovirals were not predictive of the progression of distal sensory polyneuropathy (DSP). Distal epidermal denervation was associated with worsening of DSP. As compared with the Total Neuropathy Score, the brief peripheral neuropathy screen had relatively low sensitivity and high specificity for the diagnosis of DSP.
Keywords
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