Pigment Spotting in Man and the Number of Genes Determining Skin and Eye Colour

The somatic mutation theory of pigment spotting of skin and eyes suggests that most spots seen will differ from their background by one pigmentation gene.

Abstract

The somatic mutation theory of pigment spottingof skin and eyes suggests that most spots seen will differ from their background by one pigmentation gene. The consideration of observations on skin and eyes according to this theory leads to the conclusion that skin colour is determined by a minimum of three major gene pairs and that two of these gene pairs are also largely responsible for eye colour.