Genetic susceptibility to coronary artery disease: from promise to progress
Nature Reviews GeneticsPublished 7 February 2006
Hugh Watkins, Martin Farrall
Citations210
SJR quartileQ1
SJR score16.36
SNIP6.73
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TL;DR
Findings in this work highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer.
Abstract
Family history is an important independent risk factor for coronary artery disease (CAD), and identification of susceptibility genes for this common, complex disease is a vital goal. Although there has been considerable success in identifying genetic variants that influence well-known risk factors, such as cholesterol levels, progress in unearthing novel CAD genes has been slow. However, advances are now being made through the application of large-scale, systematic, genome-wide approaches. Recent findings particularly highlight the link between CAD and inflammation and immunity, and highlight the biological insights to be gained from a genetic understanding of the world's biggest killer.
Keywords
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