Aging-Dependent Changes in the Radiation Response of the Adult Rat Brain
International Journal of Radiation Oncology*Biology*PhysicsPublished 2 January 2008Open access
Matthew K. Schindler, M. Elizabeth Forbes, Mike E. Robbins, David R. Riddle
Citations103
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TL;DR
Age is an important factor to consider when investigating the radiation response of the brain and older rats show no sustained decrease in number of immature neurons after WBI, but have a greater inflammatory response.
Abstract
Age is an important factor to consider when investigating the radiation response of the brain. In contrast to young adults, older rats show no sustained decrease in number of immature neurons after WBI, but have a greater inflammatory response. The latter may have an enhanced role in the development of radiation-induced cognitive dysfunction in older individuals.
Keywords
MedicineNeuroscience
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