Transgenic mouse model for the fragile X syndrome
American Journal of Medical GeneticsPublished 9 August 1996
R. Frank Kooy, Rudi D’Hooge, Edwin Reyniers, Cathy E. Bakker, Guy Nagels, Kristel De Boulle
Citations180
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TL;DR
It is concluded that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome.
Abstract
Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmr1 knockout mouse is a reliable transgenic model to study the fragile X syndrome.
Keywords
NeuroscienceBiochemistry, Genetics and Molecular Biology
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