Inhibition of [<sup>3</sup>H] glutamate release from rat hippocam pal slices by L‐phenylisopropyladenosine
Acta Physiologica ScandinavicaPublished 1 September 1985
Johan Fastbom, Bertil B. Fredholm
Citations142
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TL;DR
The results indicate that there are adenosine receptors modulating the efflux of glutamate in field stimulated hippocampal slices and that there is a role for L-PIA in this response.
Abstract
Hippocampal slices were labelled with [3H]glutamate. Evoked release, which was calcium-dependent and inhibited by tetrodotoxin, could be reduced concentration-dependently by L-PIA. The effect of L-PIA was blocked by 10 microM 8-phenyltheophylline. The results indicate that there are adenosine receptors modulating the efflux of glutamate in field stimulated hippocampal slices.
Keywords
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