Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers
Archives of General PsychiatryPublished 1 December 2000
Daniel Umbricht, Liselotte Schmid, R. Koller, Franz X. Vollenweider, Daniel Hell, Daniel C. Javitt
Citations583
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TL;DR
Ketamine induced performance deficits in the AX-CPT characterized by decreased hit rates and specific increases of errors (BX errors), reflecting a failure to form and use transient memory traces of task relevant information.
Abstract
The NMDARs are critically involved in human MMN generation. Deficient MMN in schizophrenia thus suggests deficits in NMDAR-related neurotransmission. N-methyl-D-aspartate receptor dysfunction may also contribute to the impairment of patients with schizophrenia in forming and using transient memory traces in more complex tasks, such as the AX-CPT. Thus, NMDAR-related dysfunction may underlie deficits in transient memory at different levels of information processing in schizophrenia. Arch Gen Psychiatry. 2000;57:1139-1147.
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