Catalytic Asymmetric 1,3-Dipolar Cycloaddition Reactions of Azomethine Ylides—A Simple Approach to Optically Active Highly Functionalized Proline Derivatives
Angewandte Chemie International EditionPublished 14 November 2002Open access
Aase Sejr Gothelf, Kurt V. Gothelf, Rita G. Hazell, Karl Anker Jørgensen
Citations265
SJR quartileQ1
SJR score5.55
SNIP2.47
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Abstract
Highly substituted pyrrolidines 4 are formed in a highly diastereo- and enantioselective 1,3-dipolar cycloaddition reaction of azomethine ylides with electron-deficient alkenes 2. The azomethine ylides are generated from glycinates 1 catalyzed by a chiral zinc(II) bisoxazoline catalyst 3.
Keywords
ChemistryPharmacology, Toxicology and Pharmaceutics