The modular phosphorylation and activation of p70<sup>s6k</sup>
FEBS LettersPublished 23 June 1997Open access
Nick Pullen, George Thomas
Citations538
SJR quartileQ1
SJR score1.22
SNIP0.77
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TL;DR
A model of activation is proposed which divides p70s6k into four functional modules that cooperate in leading to full enzyme activity and it is suggested how candidate effectors of p70S6k activation might function by directing the phosphorylation of specific sites.
Abstract
The activation of p70s6k is accompanied by a complex series of phosphorylation events. In this review we propose a model of activation which divides p70s6k into four functional modules that cooperate in leading to full enzyme activity. In the light of the model, we suggest how candidate effectors of p70s6k activation might function by directing the phosphorylation of specific sites.
Keywords
Materials ScienceBiochemistry, Genetics and Molecular Biology
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