Neosurugatoxin blocks nicotinic acetylcholine receptors in the brain
Neurochemistry InternationalPublished 1 January 1985
Catherine Rapier, Roger Harrison, George G. Lunt, Susan Wonnacott
Citations45
SJR quartileQ2
SJR score1.19
SNIP0.91
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TL;DR
The results support the view that functional nicotinic receptors in the CNS resemble ganglionic nicotinIC receptors.
Abstract
Neosurugatoxin, a neurotoxin isolated from the Japanese ivory mollusc (Babylonia japonica ) is a nicotinic antagonist with a specificity towards ganglionic nicotinic receptors. At low concentration (5 x 10(?8) M) neosurugatoxin inhibited the release of [(3)H]dopamine evoked by 1,1-dimethyl-4-phenylpiperazinium (DMPP) from rat striatal nerve terminals, without affecting the response to K(+)-depolarisation. In contrast, ?bungarotoxin did not antagonise the action of DMPP. Neosurugatoxin also inhibited [(3)H] nicotine binding to rat brain membranes but had no effect on [(125)I]?bungarotoxin binding to the same tissue preparation. These results support the view that functional nicotinic receptors in the CNS resemble ganglionic nicotinic receptors. Neosurugatoxin has considerable potential as a useful probe for such receptors in the brain.
Keywords
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