Catalytic Stereoselective Synthesis of Highly Substituted Indanones via Tandem Nazarov Cyclization and Electrophilic Fluorination Trapping
Organic LettersPublished 13 July 2007
Jing Nie, Hongwei Zhu, Han‐Feng Cui, Mingqing Hua, Jun‐An Ma
Citations151
SJR quartileQ1
SJR score1.24
SNIP1.03
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TL;DR
Three examples of catalytic enantioselective tandem transformation are presented.
Abstract
A new catalytic stereoselective tandem transformation via Nazarov cyclization/electrophilic fluorination has been accomplished. This sequence is efficiently catalyzed by a Cu(II) complex to afford fluorine-containing 1-indanone derivatives with two new stereocenters with high diastereoselectivity (trans/cis up to 49/1). Three examples of catalytic enantioselective tandem transformation are presented.
Keywords
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