Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia
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TL;DR
Preliminary evidence indicates that this reduced glutamate content is not due to neuroleptic treatment, and is interpreted by the hypothesis that there is a dysfunction or degeneration of glutamatergic neurons in schizophrenia.
Abstract
In the cerebrospinal fluid of 20 schizophrenic patients the glutamate level was found to be about half the normal value, whereas the serum glutamate was not altered. Preliminary evidence indicates that this reduced glutamate content is not due to neuroleptic treatment. The glutamate decrease is interpreted by the hypothesis that there is a dysfunction or degeneration of glutamatergic neurons in schizophrenia.