Mortality from neonatal diaphragmatic hernia
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TL;DR
All efforts to treat infants with diaphragmatic hernia will continue to be in the direction of pharmacologic manipulation of pulmonary arterial pressure and the rate of ductal closure, including direct measurements of PaO 2 above and below the ductus.
Abstract
Abstract The ability of the newborn to reestablish a fetal-type eirculation is potentially lethal in infants with diaphragmatic hernia operated upon on the first day of life. The responses of their pulmonary vasculature to all stimuli are exaggerated. Our efforts to treat them will continue to be in the direction of pharmacologic manipulation of pulmonary arterial pressure and the rate of ductal closure. To do so, it is necessary to have direct measurements of PaO 2 above and below the ductus, so that changes in shunt can be interpreted.