Modulatory role of serotonin in neural information processing: Implications for human psychopathology.
Psychological BulletinPublished 1 January 1992
Michele Spoont
Citations413
SJR quartileQ1
SJR score8.70
SNIP8.94
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TL;DR
Investigation of the role of 5-hydroxytryptophan (5-HT), which functions as a modulator in the central nervous system, across behavioral contexts suggests that a general principle of transmitter function may be derived that is independent of specific behaviors and specific neural loci.
Abstract
Investigation of the role of 5-hydroxytryptophan (5-HT), which functions as a modulator in the central nervous system, across behavioral contexts suggests that a general principle of transmitter function may be derived that is independent of specific behaviors and specific neural loci. A functional principle of 5-HT action in neural information processing in the central nervous system is proposed. Extremes deviations in 5-HT activity result in biases in information processing that may have direct effects on behavior. Such biases may predispose to pathological conditions such as violent suicide and aggression.
Keywords
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The organization of indoleamine‐containing neurons throughout the CNS of Macaca mulatta was examined with Falck‐Hillarp histofluorescnce and radioenzymatic biochemical techniques and Ascending indolaemine‐containing fiber bundles, similar to those defined in nonprimate mammals, were observed within the pons and mesencephalon.
Progress in brain researchCholinergic and Serotonergic Systems in the Brain and Spinal Cord: Anatomic Organization, Role in Intercellular Communication Processes, and Interactive Mechanisms
58 Citations1982Larry L. Butcher, Nancy J. Woolf
This chapter examines some of the issues surrounding the use of correlative electrophysiologic, immunohistochemical, traditional histochemical, and retrograde and anterograde tracing procedures in the study of chemical neuroanatomy and focuses on two neurochemicals thought to be important for information flow in the nervous system.
Behavioral and Neural BiologyEffects of serotonergic lesions on investigatory responding by rats in a holeboard
57 Citations1980Mark A. Geyer, Lyle R. Petersen +1 more
The effects of electrolytic raphe lesions on behavioral measures of reactivity are better related to depletions of forebrain serotonin than are the effects of these lesions on measures of activity or investigatory behavior.
Pharmacology Biochemistry and BehaviorThe involvement of nigral serotonin innervation in the control of punishment-induced behavioral inhibition in rats
57 Citations1983Marie-Hélène Thiébot, M. Hamon +1 more
Findings suggest an involvement of serotonergic raphé-nigral neurons in experimentally-elicited anxiety.
Behavioral NeuroscienceA proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats.
57 Citations1985Lynne M. Adams, Mark A. Geyer
The possibility that LSD's enhancement of neophobia in rats may be a valid analogue model of its intensification of affective reactions in humans is discussed.
PsychopharmacologyEnhancement of the memory of a previously learned aversive habit following pre-test administration of a variety of serotonergic antagonists in mice
57 Citations1986H.J. Altman, HowardJ. Normile
Support is provided for an important role for serotonin in the processes underlying learning and memory in the mouse.
Brain ResearchEffects of stimulating the dorsal raphe nucleus of the rat on neuronal activity in the dorsal lateral geniculate nucleus
56 Citations1989Yukihiko Kayama, Soukichi Shimada +2 more
It is suggested that serotonin released from terminals of DRN neurons exerts long-latency and long-lasting inhibition of LGNd relay neurons, the serotonergic projection from the DRN acts to control excitation levels of the forebrain.
Neuropharmacology of The Sleep-Waking Cycle
56 Citations1977Michel Jouvet
Neuropharmacology has allowed us to dissect some of the intimate mechanisms underlying the sleep-waking cycle since some drugs may suppress both states of sleep, or suppress paradoxical sleep selectively, or restore physiological sleep in an insomniac cat.
PsychopharmacologyThe use of extinction to investigate the nature of neuroleptic-induced avoidance deficits
55 Citations1980Richard J Beninger, Stephen T. Mason +2 more
The acquisition of responding in the extinction group trained under pimozide indicated that the association of environmental stimuli with shock had been learned during training in spite of the failure to avoid, and dopamine plays a role in mechanisms of response learning.
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