A study on the mechanism of impulse transmission across the giant synapse of the squid
The Journal of PhysiologyPublished 29 August 1958Open access
Susumu Hagiwara, Ichiji Tasaki
Citations219
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TL;DR
An attempt is made to elucidate the mechanism of impulse transmission across this giant synapse of the squid by using various techniques.
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Agricultural and Biological SciencesNeuroscience
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The importance of ionic movements in excitable tissues has been emphasized by a number of recent experiments which are consistent with the theory that nervous conduction depends on a specific increase in permeability which allows sodium ions to move from the more concentrated solution outside a nerve fibre to the more dilute solution inside it.
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The immediate concern of the present work is to determine the electric charge which passes through the end-plate membrane during the transmission of one impulse and to throw some light on the mechanism by which the transfer of ions across theend-plate is brought about.
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383 Citations1956A. W. Liley
In the present investigation a study has been made by intracellular recordings in the rat diaphragm of the relation between the frequency of the miniature discharge and electrotonic polarization of the motor nerve terminals.
The Journal of General PhysiologyDEMONSTRATION OF TWO STABLE POTENTIAL STATES IN THE SQUID GIANT AXON UNDER TETRAETHYLAMMONIUM CHLORIDE
323 Citations1957Ichiji Tasaki, Susumu Hagiwara
Experimental results were interpreted as supporting the view that there are two stable states in the membrane, and experimental evidence was presented showing that, in an "unstable" state, the membrane conductance is not uniquely determined by the membrane potential.
The Journal of PhysiologyChanges in end‐plate activity produced by pre‐synaptic polarization
287 Citations1954J. del Castillo, B. Katz
By passing polarizing currents through the terminal portion of a motor axon and studying their effects from the other side of the synapse, it was hoped to get further information on the neuromuscular mechanism.
NatureMechanism of Nerve-Impulse Transmission at a Crayfish Synapse
143 Citations1957E. J. Furshpan, Dave Potter
In most experiments the preparations were not in as good condition and only a synaptic potential was recorded from the post-fibre, so it is difficult to assign a value to the delay between pre-spike and synaptic response.
The Journal of General PhysiologyINTRACELLULAR RECORDING FROM THE GIANT SYNAPSE OF THE SQUID
107 Citations1957Theodore H. Bullock, Susumu Hagiwara
It is concluded after examination of both intra- and extracellular recordings that there is a real synaptic delay of the order of 1 or 2 milliseconds at 15–20°C, and transmission cannot be electrical.
Experimental Biology and MedicineUltrastructure of Two Invertebrate Synapses.
107 Citations1953J. David Robertson
Electron microscope studies of a type of physiologically polarized synapse in the crayfish and the squid have shown that the synapse consists of a region characterized by processes of postsynaptic axoplasm lying in presynaptic Schwann cell cytoplasm.
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102 Citations1939J. C. Eccles, W. J. O’Connor
