Changes in brain glucose metabolism in cocaine dependence and withdrawal
American Journal of PsychiatryPublished 1 May 1991
Nora D. Volkow, Joanna S. Fowler, Alfred P. Wolf, R. Hitzemann, Stephen L. Dewey, B. Bendriem
Citations458
SJR quartileQ1
SJR score5.27
SNIP3.68
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TL;DR
The selectivity of changes in glucose metabolism for the basal ganglia and for the orbitofrontal cortex suggests that the regional metabolic changes seen in cocaine abusers during detoxification are related to changes in brain dopamine activity.
Abstract
Although the time-dependent fall in metabolic activity suggests that the higher metabolic activity observed less than a week after cocaine withdrawal may represent a nonspecific expression of drug withdrawal, the selectivity of changes in glucose metabolism for the basal ganglia and for the orbitofrontal cortex suggests that the regional metabolic changes seen in cocaine abusers during detoxification are related to changes in brain dopamine activity.
Keywords
MedicineNeuroscience
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