Plasma Cell Pleocytosis in Cerebrospinal Fluid in Patients with West Nile Virus Encephalitis
Clinical Infectious DiseasesPublished 1 July 2003
Paul J. Carson, Thomas Steidler, Roberto L. Patron, John M. Tate, Robert R. Tight, Raymond A. Smego
Citations25
SJR quartileQ1
SJR score2.99
SNIP2.01
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TL;DR
The finding of significant numbers of plasma cells in CSF may serve as a useful early diagnostic clue for West Nile virus encephalitis.
Abstract
We describe 4 patients with West Nile virus encephalitis who all displayed previously unreported plasma cell pleocytosis of the cerebrospinal fluid (CSF). Three patients recovered but had varying degrees of mild neurologic disability on discharge from the hospital, and 1 patient died. The finding of significant numbers of plasma cells in CSF may serve as a useful early diagnostic clue for West Nile virus encephalitis.
Keywords
Medicine
New England Journal of MedicineThe Outbreak of West Nile Virus Infection in the New York City Area in 1999
1,357 Citations2001Denis Nash, Farzad Mostashari +16 more
Emerging infectious diseasesEfficacy of Interferon α-2b and Ribavirin against <i>West Nile Virus</i> In Vitro
216 Citations2002John F. Anderson, James J. Rahal
Clinical cases in which autologous grafts or Christensen joint prosthesis are employed in temporomandibular joint reconstruction are described.
Journal of Clinical MicrobiologyEvaluation of Immunoglobulin M (IgM) and IgG Enzyme Immunoassays in Serologic Diagnosis of West Nile Virus Infection
192 Citations2000Grațiela Ţârdei, S. Ruta +4 more
New England Journal of MedicineWest Nile Virus Encephalitis in America
50 Citations2001Kenneth L. Tyler
In the United States, most cases of acute encephalitis are caused by herpes simplex virus, enteroviruses, and arthropod-borne viruses (arbovirus), and only arbovIRuses produce epidemics of viral encephalopathy.
NeurologyAseptic meningitis following cardiac transplantation
42 Citations1991John C. Adair, Susan Woodley +3 more
Of 29 patients from the Utah Cardiac Transplant Program who had lumbar puncture because of change in neurologic function, or to assess fever of uncertain etiology, CSF pleocytosis was present in 14 patients, 4 of whom had an active infectious process involving the nervous system.
InfectionCytological and immunoglobulin findings in cerebrospinal fluid of symptomatic and asymptomatic human immunodeficiency virus (HIV) seropositive patients
30 Citations1988Lars Hagberg, Gunnar Norkrans +3 more
The results indicate that HIV has a high neurotropicity and is spread to CNS in all stages of the infection.
PubMedSleeping sickness and the central nervous system.
22 Citations1994V. W. Pentreath, P J Baugh +1 more
The immunopathology in the CNS may be brought about by elevated levels of active substances in the cerebrospinal fluid, caused by parasite infection.
PubMedCytologic features of cerebrospinal fluid in Lyme disease.
21 Citations1987F. Razavi-Encha, J Fleury-Feith +2 more
The cytomorphologic findings in the cerebrospinal fluid of four patients with lymphocytic meningoradiculitis related to a tick bite can be considered as suggestive of the spirochetal origin of a lymphocytics meningitis following atick bite.
European NeurologyCSF Cytology of Acute Viral Meningitis and Meningoencephalitis
17 Citations2008S Pelc, Emilie De Maertelaere +1 more
The CSF of 12 patients with acute meningitis and meningoencephalitis of viral nature and various lymphoid cell features of marked immune activation were disclosed in association, including cell polymorphism, normal-appearing mitosis and binucleation, abnormal nuclear lobulation and even partition, as well as Russell bodies, morular appearance and clasmatosis in plasma cells.
PubMedPhenotypic analysis of cerebrospinal fluid cells over the course of Lyme meningoradiculitis.
15 Citations1995E. Sindern, J.-P. Malin
The CD4/CD8 ratio of the helper/inducer and suppressor/cytotoxic lymphocyte subsets declined in all the patients after antibiotic treatment and might be useful as a marker of the disease activity.
European NeurologyBorrelia-Induced Meningoradiculitis -Two Different Forms of the Disease
10 Citations2008Ines Klöter, Thomas Adam +3 more
The pattern of CSF cytological findings in the acute stage and after 10 days of antibiotic and steroid treatment was examined in 14 patients with meningoradiculitis due to an arthropode-transmitted infection with Borrelia duttoni.
DMW - Deutsche Medizinische WochenschriftDifferentialdiagnose atypischer Plasmazellen im Liquor cerebrospinalis
9 Citations2008Rainer Kraft, H. J. Altermatt +1 more
It is concluded that in a case of unexplained meningoradiculitis with lymphoplasmocytic reaction in the CSF, morphological analysis of the plasma cells can provide important diagnostic pointers.
European NeurologyZoster Meningitis and Radiculomeningitis after Tick Bite
6 Citations2008Hiroshi Shoji, D. Dommasch
Cytological changes in 9 samples of cerebrospinal fluid (CSF) from 5 patients with zoster meningitis and 12 samples from5 patients with radiculomeningitis after tick bite were examined.
PubMed[Cytologic characteristics of cerebrospinal fluid in patients with serous meningitis caused by enteroviruses, mumps virus or Koch's bacillus].
4 Citations1996Željka Tatomirović, Radojka Bokun +1 more
Differences in cytological response of CNS between ENTERO and MUMPS group were mainly quantitative and dynamic, probably caused by the various pathogenesic mechanisms of inflammation.
PubMed[Plasma cells in the cerebrospinal fluid of patients with cerebral cysticercosis].
3 Citations1990Guadalupe Bravo, Teresa Corona +3 more
It is found that plasma cells are more frequently encountered in the CSF than eosinophils in patients with cerebral cysticercosis, and this suggests a role of plasma cells in the pathogenesis of the Cysticercotic disease.
PubMedWest Nile virus activity--United States, September 19-25, 2002, and Michigan, January 1-September 24, 2002.
1 Citations2002
This report summarizes West Nile virus surveillance data reported to CDC through ArboNET and by states and other jurisdictions as of 7 a.m.
PubMed[Cerebrospinal fluid cytology of acute viral encephalitis and meningitis].
1 Citations1998Bao‐Guo Xiao, Ying Peng +5 more
Using cytological examination, the cerebrospinal fluid of 98 patients with acute viral encephalitis was investigated, and various lymphoid features were disclosed in association: mitosis, binucleation, abnormal nuclear lobulation, Russell bodies, and morula in plasma cells.
PubMed[A case of measles meningoencephalitis with marked increase of plasma cells in cerebrospinal fluid].
1 Citations1991M Nozaki, K Nakagihara +2 more
Marked increase of plasma cells in CSF of this case suggest marked B cell activation occurring in the central nervous system in measles meningoencephalitis, which is extremely rare in the literature.
