Targeted lymph-node immunization with whole inactivated simian immunodeficiency virus (SIV) or envelope and core subunit antigen vaccines does not reliably protect rhesus macaques from vaginal challenge with SIVmac251
AIDSPublished 1 January 1998Open access
Xusheng Lü, Hiroshi Kiyono, Lu Ding, Shigetada Kawabata, Judy Torten, Seema Srinivasan
Citations125
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TL;DR
In this series of studies, reliable protection from vaginal transmission of SIV was not achieved by the TILN immunization procedure.
Abstract
In this series of studies, reliable protection from vaginal transmission of SIV was not achieved by the TILN immunization procedure.
Keywords
Immunology and MicrobiologySocial SciencesMedicine
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It is suggested that the induction of Th2 type responses in TLN-immunized rhesus macaques reflects the sequence of initial induction of SIV-specific IgG-producing cells followed by IgA-secreting cells.
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