Prevention of Corticosteroid Osteoporosis -- A Comparison of Calcium, Calcitriol, and Calcitonin
New England Journal of MedicinePublished 17 June 1993
Philip N. Sambrook, J. Birmingham, Paul Kelly, Susan Kempler, Tuan V. Nguyen, Nicholas Pocock
Citations524
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
Calcitriol and calcium, used prophylactically with or without calcitonin, prevent corticosteroid-induced bone loss in the lumbar spine.
Abstract
Calcitriol and calcium, used prophylactically with or without calcitonin, prevent corticosteroid-induced bone loss in the lumbar spine.
Keywords
Medicine
BiometricsSequential Treatment Assignment with Balancing for Prognostic Factors in the Controlled Clinical Trial
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New England Journal of MedicineInvolutional Osteoporosis
1,915 Citations1986B. Lawrence Riggs, L. Joseph Melton
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Journal of Clinical InvestigationDifferential effects of endocrine dysfunction on the axial and the appendicular skeleton.
463 Citations1982Ego Seeman, Heinz W. Wahner +4 more
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Science1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene
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New England Journal of MedicineGlucocorticoid-Induced Osteoporosis
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The most disabling of these adverse effects is the development of osteopenia, which is more severe in the regions with high trabecular bone content (spine and ribs), and less striking in predominantly cortical bone areas (Hann et al, 1979).
Bone and MineralBone loss in response to long-term glucocorticoid therapy
378 Citations1990V. LoCascio, E. Bonucci +6 more
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Journal of Clinical InvestigationIntestinal Calcium Absorption in Exogenous Hypercortisonism
361 Citations1977Robert G. Klein, Sara B. Arnaud +3 more
It is suggested that calcium malabsorption in the corticosteroid-treated patients is due to a dose-related abnormality of vitamin D metabolism and not to a direct effect of Corticosteroids on depressing transmucosal intestinal absorption of calcium.
MetabolismImportance of increased urinary calcium excretion in the development of secondary hyperparathyroidism of patients under glucocorticoid therapy
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The Journal of Clinical Endocrinology & MetabolismEffects of Short Term Glucocorticoid Administration on Intestinal Calcium Absorption and Circulating Vitamin D Metabolite Concentrations in Man*
309 Citations1981Theodore J. Hahn, Linda R. Halstead +1 more
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Annals of Internal MedicineCalcitriol Treatment Is Not Effective in Postmenopausal Osteoporosis
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Metabolic Bone Disease and Related ResearchHistomorphometric profile, pathophysiology and reversibility of corticosteroid-induced osteoporosis
306 Citations1979C Bressot, Pierre J. Meunier +4 more
The results indicate that CS's induce bone rarefaction mainly by decreasing osteoblastic activity at the cell level, however, the bone loss is probably magnified by secondary hyperparathyroidism which increases the birthrate of basic multicellular bone remodelling units.
The Journal of Clinical Endocrinology & MetabolismGenetic Factors in Bone Turnover*
238 Citations1991Paul J. Kelly, John L. Hopper +4 more
The data indicate that circulating osteocalcin, and therefore bone formation, is strongly genetically determined and suggest at least one of the mechanisms of the genetic effect on bone mass relates to the regulation of bone turnover.
Annals of Internal MedicineTreatment of Postmenopausal Osteoporosis with High Doses of Synthetic Calcitriol
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The treatment of postmenopausal osteoporotic women with synthetic calcitriol for 2 years was associated with increases in spine density and total body calcium and no adverse effects on renal function were seen after long-term calcitril therapy.
Journal of Bone and Mineral ResearchCorticosteroid effects on proximal femur bone loss
188 Citations1990Philip Dr. Sambrook, J. Birmingham +6 more
The data suggest that bone loss with corticosteroids is most rapid soon after starting treatment and occurs to a similar extent from the proximal femur to the lumbar spine, and the bone loss at the femoral neck suggests an increased risk of fracture at that site, particularly in older subjects on long‐term Corticosteroid therapy.
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187 Citations1986Ian R. Reid, George E. Chapman +6 more
Serum osteocalcin (OC) levels were measured in 19 asthmatic patients receiving long term glucocorticoid therapy and in age- and sex-matched astHmatic patients not receiving this treatment, and multiple regression analysis indicated that OC correlated directly to 1,25-(OH)2D and inversely to glucoc Corticoid dose.
BMJEffect of salcatonin given intranasally on early postmenopausal bone loss.
180 Citations1989Karsten Overgaard, B.J. Riis +2 more
The results suggest that salcatonin given intranasally in the dose used prevents bone loss in the spine of early post menopausal women but does not affect the peripheral skeleton.
Journal of the American Dietetic AssociationA simple method for assessing calcium intake in Caucasian women
168 Citations1989R M Angus, Philip N. Sambrook +2 more
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167 Citations1978B. E. C. Nordin
The investigation of a patient with a suspected disorder of calcium metabolism is most rapidly and efficiently performed by observing a standard procedure.
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Arthritis & RheumatismEffect of oral 1,25‐dihydroxyvitamin D and calcium on glucocorticoid‐induced osteopenia in patients with rheumatic diseases
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Arthritis & RheumatismSex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis
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Prednisolone therapy in 22 patients (mean dosage 8 mg/day) was associated with reductions in estrone and testosterone levels; however, DHEAS and femoral BMD were also decreased in RA patients who were not receiving corticosteroids.
American Journal of Clinical NutritionCalcium supplements in the prevention of steroid-induced osteoporosis
130 Citations1986IR Reid, H.K. Ibbertson
It is concluded that calcium supplementation suppresses bone resorption without detectable suppression of indices of bone formation and is, therefore, likely to result in increased bone mass.
Calcified Tissue InternationalPrevention of corticosteroid-induced osteoporosis with salmon calcitonin in sarcoid patients
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The Journal of Clinical Endocrinology & MetabolismAge and Menopause-Related Changes in Indices of Bone Turnover*
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American Review of Respiratory DiseaseTreatment of Steroid-induced Osteopenia with Calcitonin in Corticosteroid-dependent Asthma: A One-Year Follow-up Study
108 Citations1990M Luengo, César Picado +4 more
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It is suggested that patients who are receiving prednisone should be advised to use supplemental calcium, and a small increase in BMC was noted in both groups, but no differences between preventive calcium and calcium plus Vitamin D became evident.
Journal of Clinical PathologyMeasurement of the fasting urinary hydroxyproline: creatinine ratio in normal adults and its variation with age and sex.
82 Citations1982A. Hodgkinson, Theresa L. Thompson
Feeding experiments with gelatin showed that hydroxyproline is rapidly absorbed and excreted in the urine and that a 12-hour (overnight) fast is sufficient to ensure correct and reproducible fasting OHPr: Cr ratios.
Endocrinology1,25-Dihydroxyvitamin D<sub>3</sub>Modulates Glucocorticoid-Induced Alteration in Serum Bone Gla Protein and Bone Histomorphometry
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Clinical EndocrinologyINFLUENCE OF 1α‐(OH)D<sub>3</sub> ADMINISTRATION ON BONE AND BONE MINERAL METABOLISM IN PATIENTS ON CHRONIC GLUCOCORTICOID TREATMENT; A DOUBLE BLIND CONTROLLED STUDY
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PubMedAssessment of the biological effectiveness of nasal synthetic salmon calcitonin (SSCT) by comparison with intramuscular (i.m.) or placebo injection in normal subjects.
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Assessment of the biological activity of nasal SSCT by comparing the fluctuations of parameters reflecting calcium-phosphorus metabolism after nasal instillation, injection of SSCT and injection of placebo found no changes in serum beta-endorphin, magnesium or erythrocyte magnesium levels after administration of calcitonin by the intranasal route or by injection.
PubMedBone protection with salmon calcitonin (sCT) in the long-term steroid therapy of chronic sarcoidosis.
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PubMedPostmenopausal bone loss in rheumatoid arthritis: effect of estrogens and androgens.
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The data suggest adrenal androgen status may influence bone loss in RA and that, although estrogen therapy can prevent bone loss from the spine, it may not preventBone loss at sites near involved joints.
Journal of Bone and Mineral ResearchAcute effect of 1,25-dihydroxyvitamin D3, prednisone, and 1,25-dihydroxyvitamin D3 plus prednisone on serum osteocalcin in normal individuals
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It is concluded that 1,25‐(OH)2D3 and prednisone have opposing effects on serum OC.
