On the mechanism of genetic recombination between DNA molecules
Journal of Molecular BiologyPublished 1 January 1964
Matthew Meselson
Citations144
SJR quartileQ1
SJR score2.21
SNIP1.13
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TL;DR
This and other features of the distribution of parental DNA among recombinant phages and among their descendants show that genetic recombination occurs by breakage and joining of double-stranded DNA molecules.
Abstract
A two-factor cross was performed between bacteriophages labeled with heavy isotopes. Recombinants were found with chromosomes formed entirely or almost entirely of parental DNA. This and other features of the distribution of parental DNA among recombinant phages and among their descendants show that genetic recombination occurs by breakage and joining of double-stranded DNA molecules. Also, there is some indication that a small amount of DNA is removed and resynthesized in the formation of recombinant molecules.
Keywords
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